ABCB9 transports peptides from cytosol to lysosomal lumen

Stable Identifier
Reaction [transition]
Homo sapiens
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ATP-binding cassette sub-family B member 9 (ABCB9, aka lysosomal ABC transporter associated with antigen processing-like, TAPL) is a homodimeric ATP-dependent low affinity peptide transporter (Wolters et al. 2005), localised on the lysosomal membrane (Zhang et al. 2000). It is able to transport a broad spectrum of peptides (from 6mer up to at least 59mer peptides, optimum of 23mers) from the cytosol to the lysosomal lumen. ABCB9 favours positively charged, aromatic or hydrophobic residues in the N- and C-terminal positions whereas negatively charged residues and asparagine and methionine residues are not favoured (Wolters et al. 2005, Demirel et al. 2007, Zhao et al. 2008). The reaction described here shows the transport of the optimum 23mer peptide.

Literature References
PubMed ID Title Journal Year
17977821 Identification of a lysosomal peptide transport system induced during dendritic cell development

Appel, S, Grünebach, F, Tampé, R, Brossart, P, Abele, R, Kalinke, U, Demirel, O, Hasilik, A, Waibler, Z

J. Biol. Chem. 2007
15863492 Selective and ATP-dependent translocation of peptides by the homodimeric ATP binding cassette transporter TAP-like (ABCB9)

Tampé, R, Abele, R, Wolters, JC

J. Biol. Chem. 2005
10748049 Characterization of ABCB9, an ATP binding cassette protein associated with lysosomes

Ling, V, Childs, S, Hui, D, Zhang, W, Dorovini-Zis, K, Liu, L, Zhang, F, Fisher, CL

J. Biol. Chem. 2000
18434309 Peptide specificity and lipid activation of the lysosomal transport complex ABCB9 (TAPL)

Tampé, R, Haase, W, Abele, R, Zhao, C

J. Biol. Chem. 2008
Catalyst Activity

ABC-type oligopeptide transporter activity of ABCB9 dimer [lysosomal membrane]

Orthologous Events
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