Reactome | ABCB9 transports peptides from cytosol to lysosomal lumen

ABCB9 transports peptides from cytosol to lysosomal lumen

Stable Identifier

R-HSA-5223317

Type

Reaction [transition]

Species

Homo sapiens

Compartment

cytosol, lysosomal lumen, lysosomal membrane

ReviewStatus

5/5

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ABCB9 transports peptides from cytosol to lysosomal lumen

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ATP-binding cassette sub-family B member 9 (ABCB9, aka lysosomal ABC transporter associated with antigen processing-like, TAPL) is a homodimeric ATP-dependent low affinity peptide transporter (Wolters et al. 2005), localised on the lysosomal membrane (Zhang et al. 2000). It is able to transport a broad spectrum of peptides (from 6mer up to at least 59mer peptides, optimum of 23mers) from the cytosol to the lysosomal lumen. ABCB9 favours positively charged, aromatic or hydrophobic residues in the N- and C-terminal positions whereas negatively charged residues and asparagine and methionine residues are not favoured (Wolters et al. 2005, Demirel et al. 2007, Zhao et al. 2008). The reaction described here shows the transport of the optimum 23mer peptide.

Literature References

PubMed ID	Title	Journal	Year
17977821	Identification of a lysosomal peptide transport system induced during dendritic cell development Demirel, O, Waibler, Z, Kalinke, U, Grünebach, F, Appel, S, Brossart, P, Hasilik, A, Tampé, R, Abele, R	J. Biol. Chem.	2007
15863492	Selective and ATP-dependent translocation of peptides by the homodimeric ATP binding cassette transporter TAP-like (ABCB9) Wolters, JC, Abele, R, Tampé, R	J. Biol. Chem.	2005
10748049	Characterization of ABCB9, an ATP binding cassette protein associated with lysosomes Zhang, F, Zhang, W, Liu, L, Fisher, CL, Hui, D, Childs, S, Dorovini-Zis, K, Ling, V	J. Biol. Chem.	2000
18434309	Peptide specificity and lipid activation of the lysosomal transport complex ABCB9 (TAPL) Zhao, C, Haase, W, Tampé, R, Abele, R	J. Biol. Chem.	2008