MTHFD1 dimer ligates HCOOH to THFPG to form 10-formyl-THFPG

Stable Identifier
R-HSA-200711
Type
Reaction
Species
Homo sapiens
Compartment
Synonyms
THF polyglutamate + formate + ATP => 10-formylTHF polyglutamate + ADP + orthophosphate
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The formate-tetrahydrofolate ligase activity of the trifunctional MTHFD1 enzyme catalyzes the reaction of THF polyglutamate, formate, and ATP to form 10-formylTHF polyglutamate, ADP, and orthophosphate. MTHFD1 is cytosolic and occurs as a dimer. The human enzyme has been identified and partially characterized biochemically (Hum et al. 1988); additional reaction details can be inferred from the properties of the well-studied homologous rabbit enzyme (Villar et al. 1985).

Participants
Participates
Catalyst Activity

formate-tetrahydrofolate ligase activity of MTHFD1 dimer [cytosol]

Orthologous Events
Created
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