Reactome | HDHD1:Mg2+ dephosphorylates PURIDP

HDHD1:Mg2+ dephosphorylates PURIDP

Stable Identifier

R-HSA-6788295

Type

Reaction [transition]

Species

Homo sapiens

Compartment

cytosol

ReviewStatus

5/5

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Pseudouridine 5'-phosphate (PURIDP) is a potential intermediate in RNA degradation. Pseudouridine 5'-phosphatase (HDHD1) is a Mg2+-dependent enzyme present in erythrocytes that can dephosphorylate PURIDP to pseudouridine (PURID), the fifth-most abundant nucleoside in RNA. PURID is not metabolised in mammals but excreted intact in urine (Preumont et al. 2010).

Literature References

PubMed ID	Title	Journal	Year
20722631	HDHD1, which is often deleted in X-linked ichthyosis, encodes a pseudouridine-5'-phosphatase Preumont, A, Rzem, R, Vertommen, D, Van Schaftingen, E	Biochem. J.	2010