HDHD1:Mg2+ dephosphorylates PURIDP

Stable Identifier
R-HSA-6788295
Type
Reaction [transition]
Species
Homo sapiens
Compartment
cytosol
Locations in the PathwayBrowser
Expand all
General
SVG | 
PNG
Low
Medium
High
 | PPTX  | SBGN
HDHD1:Mg2+ dephosphorylates PURIDP
Click the image above or here to open this reaction in the Pathway Browser
The layout of this reaction may differ from that in the pathway view due to the constraints in pathway layout

Pseudouridine 5'-phosphate (PURIDP) is a potential intermediate in RNA degradation. Pseudouridine 5'-phosphatase (HDHD1) is a Mg2+-dependent enzyme present in erythrocytes that can dephosphorylate PURIDP to pseudouridine (PURID), the fifth-most abundant nucleoside in RNA. PURID is not metabolised in mammals but excreted intact in urine (Preumont et al. 2010).

Literature References
PubMed ID Title Journal Year
20722631 HDHD1, which is often deleted in X-linked ichthyosis, encodes a pseudouridine-5'-phosphatase

Preumont, A, Rzem, R, Vertommen, D, Van Schaftingen, E

Biochem. J. 2010
Participants
Input
Output
Participant Of
hasEvent
Catalyst Activity
Catalyst Activity
Title
hydrolase activity of HDHD1:Mg2+ [cytosol]
Physical Entity
HDHD1:Mg2+ [cytosol]
Activity
hydrolase activity (0016787)
Orthologous Events
HDHD1:Mg2+ dephosphorylates PURIDP (Bos taurus)
HDHD1:Mg2+ dephosphorylates PURIDP (Caenorhabditis elegans)
HDHD1:Mg2+ dephosphorylates PURIDP (Canis familiaris)
HDHD1:Mg2+ dephosphorylates PURIDP (Danio rerio)
HDHD1:Mg2+ dephosphorylates PURIDP (Drosophila melanogaster)
HDHD1:Mg2+ dephosphorylates PURIDP (Gallus gallus)
HDHD1:Mg2+ dephosphorylates PURIDP (Mus musculus)
HDHD1:Mg2+ dephosphorylates PURIDP (Rattus norvegicus)
HDHD1:Mg2+ dephosphorylates PURIDP (Saccharomyces cerevisiae)
HDHD1:Mg2+ dephosphorylates PURIDP (Schizosaccharomyces pombe)
HDHD1:Mg2+ dephosphorylates PURIDP (Sus scrofa)
HDHD1:Mg2+ dephosphorylates PURIDP (Xenopus tropicalis)
Cross References
Rhea
Authored
Jassal, B  (2015-07-20)
Reviewed
D'Eustachio, P  (2015-09-14)
Created
Jassal, B  (2015-07-20)