Reactome | HDHD1:Mg2+ dephosphorylates PURIDP

HDHD1:Mg2+ dephosphorylates PURIDP

Stable Identifier

R-HSA-6788295

Type

Reaction

Species

Homo sapiens

Compartment

cytosol

Locations in the PathwayBrowser

Expand all

General

SBML | | PDF

SVG | | PPTX | SBGN

Click the image above or here to open this reaction in the Pathway Browser
The layout of this reaction may differ from that in the pathway view due to the constraints in pathway layout

Pseudouridine 5'-phosphate (PURIDP) is a potential intermediate in RNA degradation. Pseudouridine 5'-phosphatase (HDHD1) is a Mg2+-dependent enzyme present in erythrocytes that can dephosphorylate PURIDP to pseudouridine (PURID), the fifth-most abundant nucleoside in RNA. PURID is not metabolised in mammals but excreted intact in urine (Preumont et al. 2010).

Literature References

PubMed ID	Title	Journal	Year
20722631	HDHD1, which is often deleted in X-linked ichthyosis, encodes a pseudouridine-5'-phosphatase Preumont, A, Rzem, R, Vertommen, D, Van Schaftingen, E	Biochem. J.	2010