Reactome | NSF ATPase activity dissociates cis-SNARE at cis-Golgi

NSF ATPase activity dissociates cis-SNARE at cis-Golgi

Stable Identifier

R-HSA-6809015

Type

Reaction [uncertain]

Species

Homo sapiens

Compartment

Golgi membrane

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Metabolism of proteins (Homo sapiens)

- Post-translational protein modification (Homo sapiens)
  - Asparagine N-linked glycosylation (Homo sapiens)
    - Transport to the Golgi and subsequent modification (Homo sapiens)
      - ER to Golgi Anterograde Transport (Homo sapiens)
        
        COPI-mediated anterograde transport (Homo sapiens)
        
        NSF ATPase activity dissociates cis-SNARE at cis-Golgi (Homo sapiens)

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NSF ATPase activity dissociates cis-SNARE at cis-Golgi

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NSF-dependent hydrolysis of ATP is required to disassociate the cis-SNARE complex, releasing the SNAREs for further rounds of membrane fusion (Mayer et al, 1996; Muller et al, 1999; Muller et al, 2002; Otto et al, 1997; Whiteheart et al, 2004; Yu et al, 1999; Zhao et al, 2012; Shah et al, 2015; reviewed in Sudhof and Rothman, 2009).

Literature References

PubMed ID	Title	Journal	Year
9177194	Assembly and disassembly of a ternary complex of synaptobrevin, syntaxin, and SNAP-25 in the membrane of synaptic vesicles Otto, H, Hanson, PI, Jahn, R	Proc. Natl. Acad. Sci. U.S.A.	1997
8620540	Sec18p (NSF)-driven release of Sec17p (alpha-SNAP) can precede docking and fusion of yeast vacuoles Mayer, A, Wickner, W, Haas, A	Cell	1996
25492864	Three ?SNAP and 10 ATP molecules are used in SNARE complex disassembly by N-ethylmaleimide-sensitive factor (NSF) Shah, N, Colbert, KN, Enos, MD, Herschlag, D, Weis, WI	J. Biol. Chem.	2015
10445031	NSF N-terminal domain crystal structure: models of NSF function Yu, RC, Jahn, R, Brunger, AT	Mol. Cell	1999
15037235	Multiple binding proteins suggest diverse functions for the N-ethylmaleimide sensitive factor Whiteheart, SW, Matveeva, EA	J. Struct. Biol.	2004
19164740	Membrane fusion: grappling with SNARE and SM proteins Südhof, TC, Rothman, JE	Science	2009
21689688	Requirements for the catalytic cycle of the N-ethylmaleimide-Sensitive Factor (NSF) Zhao, C, Smith, EC, Whiteheart, SW	Biochim. Biophys. Acta	2012
10559959	An NSF function distinct from ATPase-dependent SNARE disassembly is essential for Golgi membrane fusion Müller, JM, Rabouille, C, Newman, R, Shorter, J, Freemont, P, Schiavo, G, Warren, G, Shima, DT	Nat. Cell Biol.	1999
12070132	Sequential SNARE disassembly and GATE-16-GOS-28 complex assembly mediated by distinct NSF activities drives Golgi membrane fusion Muller, JM, Shorter, J, Newman, R, Deinhardt, K, Sagiv, Y, Elazar, Z, Warren, G, Shima, DT	J. Cell Biol.	2002