Reactome | ABCA7:Apo1A-mediated phospholipid efflux

ABCA7:Apo1A-mediated phospholipid efflux

Stable Identifier

R-HSA-382553

Type

Reaction [transition]

Species

Homo sapiens

Compartment

cytosol, plasma membrane, extracellular region

ReviewStatus

5/5

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ABCA7:Apo1A-mediated phospholipid efflux

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ABCA7 has the ability to bind apolipoproteins and promote efflux of cellular phospholipids and may have a possible role in cellular phospholipid metabolism in peripheral tissues. Like many other ABC-transporters, the exact role of ABCA7 is waiting to be elucidated.

Literature References

PubMed ID	Title	Journal	Year
11095984	Genomic organization of the human cholesterol-responsive ABC transporter ABCA7: tandem linkage with the minor histocompatibility antigen HA-1 gene Kaminski, WE, Piehler, A, Schmitz, G	Biochem Biophys Res Commun	2000
14570867	Human ABCA7 supports apolipoprotein-mediated release of cellular cholesterol and phospholipid to generate high density lipoprotein Abe-Dohmae, S, Ikeda, Y, Matsuo, M, Hayashi, M, Okuhira, K, Ueda, K, Yokoyama, S	J Biol Chem	2004
12509503	Role of ABC transporters in secretion of cholesterol from liver into bile Small, DM	Proc Natl Acad Sci U S A	2003
14592415	Posttranscriptional regulation of human ABCA7 and its function for the apoA-I-dependent lipid release Ikeda, Y, Abe-Dohmae, S, Munehira, Y, Aoki, R, Kawamoto, S, Furuya, A, Shitara, K, Amachi, T, Kioka, N, Matsuo, M, Yokoyama, S, Ueda, K	Biochem Biophys Res Commun	2003
12917409	ATP-binding cassette transporter A7 (ABCA7) binds apolipoprotein A-I and mediates cellular phospholipid but not cholesterol efflux Wang, N, Lan, D, Gerbod-Giannone, M, Linsel-Nitschke, P, Jehle, AW, Chen, W, Martinez, LO, Tall, AR	J Biol Chem	2003
10873640	Identification of a novel human sterol-sensitive ATP-binding cassette transporter (ABCA7) Kaminski, WE, Orsó, E, Diederich, W, Klucken, J, Drobnik, W, Schmitz, G	Biochem Biophys Res Commun	2000