Dephosphorylation of inactive SRC by PTPB1

Stable Identifier
R-HSA-377643
Type
Reaction [transition]
Species
Homo sapiens
Compartment
cytosol, plasma membrane
ReviewStatus
5/5
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Dephosphorylation of inactive SRC by PTPB1
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The integrin alphaIIb beta3:Inactive SRC complex recruits PTP1B protein tyrosine phosphatase resulting in the dephosphorylation of SRC tyrosine 530. The phosphorylated tail of SRC tail interacts with the SH2 domain thereby repressing kinase activity; removal of phosphorylation activates SRC kinase activity.

Literature References
PubMed ID Title Journal Year
16115959 PTP-1B is an essential positive regulator of platelet integrin signaling

Furie, B, Dubois, C, Moran, B, Kasirer-Friede, A, Neel, BG, Arias-Salgado, EG, Shattil, SJ, Furie, BC, Haj, F

J Cell Biol 2005
16005629 Integrins and Src: dynamic duo of adhesion signaling

Shattil, SJ

Trends Cell Biol 2005
Participants
Input
Output
Participates
as an event of
Catalyst Activity

protein tyrosine phosphatase activity of PTPN1 [cytosol]

Physical Entity
PTPN1 [cytosol] (Homo sapiens)
Activity
protein tyrosine phosphatase activity (GO:0004725)
Orthologous Events
Dephosphorylation of inactive SRC by PTPB1 (Bos taurus)
Dephosphorylation of inactive SRC by PTPB1 (Canis familiaris)
Dephosphorylation of inactive SRC by PTPB1 (Danio rerio)
Dephosphorylation of inactive SRC by PTPB1 (Drosophila melanogaster)
Dephosphorylation of inactive SRC by PTPB1 (Gallus gallus)
Dephosphorylation of inactive SRC by PTPB1 (Mus musculus)
Dephosphorylation of inactive SRC by PTPB1 (Rattus norvegicus)
Dephosphorylation of inactive SRC by PTPB1 (Sus scrofa)
Authored
Garapati, P V  (2008-06-16)
Reviewed
Shattil, SJ  (2008-09-16)
Created
Garapati, P V  (2008-09-15)
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