APS is phosphorylated to PAPS

Stable Identifier
R-MTU-936583
Type
Reaction [transition]
Species
Mycobacterium tuberculosis
Compartment
cytosol
ReviewStatus
5/5
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APS is phosphorylated to PAPS
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The layout of this reaction may differ from that in the pathway view due to the constraints in pathway layout
Energy for the phosphorylation of APS comes from the hydrolysis of a GTP molecule. The resulting PAPS is used in M. tuberculosis by several sulfotransferases for the production of sulfolipids (Pinto et al, 2004; Sun et al, 2005).
Literature References
PubMed ID Title Journal Year
15615729 The trifunctional sulfate-activating complex (SAC) of Mycobacterium tuberculosis

Sun, M, Andreassi JL, 2nd, Liu, S, Pinto, R, Triccas, JA, Leyh, TS

J Biol Chem 2005
15184554 The Mycobacterium tuberculosis cysD and cysNC genes form a stress-induced operon that encodes a tri-functional sulfate-activating complex

Pinto, R, Tang, QX, Britton, WJ, Leyh, TS, Triccas, JA

Microbiology 2004
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Catalyst Activity

adenylylsulfate kinase activity of sulfate adenylyltransferase complex [cytosol]

Physical Entity
sulfate adenylyltransferase complex [cytosol] (Mycobacterium tuberculosis)
Activity
adenylylsulfate kinase activity (GO:0004020)
Authored
Stephan, R  (2010-06-18)
Reviewed
Warner, D  (2010-11-25)
Created
Jassal, B  (2010-08-24)
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