DHAP from Ery4P and PEP

Stable Identifier
R-MTU-964912
Type
Reaction [transition]
Species
Mycobacterium tuberculosis
Compartment
cytosol
ReviewStatus
5/5
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DHAP from Ery4P and PEP
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The first committed step in the biosynthesis of chorismate is the fusion of D-erythrose-4-phosphate with phosphoenolpyruvate, catalyzed by AroG (Rizzi et al, 2005; Webby et al, 2005).

Literature References
PubMed ID Title Journal Year
15721768 DAHP synthase from Mycobacterium tuberculosis H37Rv: cloning, expression, and purification of functional enzyme

Basso, LA, Oliveira, JS, da Fonseca, IO, Weber, PG, Santos, DS, Palma, MS, Rizzi, C, Frazzon, J, Gallas, M, Ely, F, de Souza, BM, Mendes, MA

Protein Expr Purif 2005
16288916 The structure of 3-deoxy-d-arabino-heptulosonate 7-phosphate synthase from Mycobacterium tuberculosis reveals a common catalytic scaffold and ancestry for type I and type II enzymes

Baker, HM, Webby, CJ, Parker, EJ, Baker, EN, Lott, JS

J Mol Biol 2005
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Catalyst Activity

3-deoxy-7-phosphoheptulonate synthase activity of AroG-Mn++ pentamer [cytosol]

Physical Entity
AroG-Mn++ pentamer [cytosol] (Mycobacterium tuberculosis)
Activity
3-deoxy-7-phosphoheptulonate synthase activity (GO:0003849)
Authored
Stephan, R  (2010-09-13)
Reviewed
Warner, D  (2010-11-25)
Created
Jassal, B  (2010-09-20)
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