PI(3,5)P2 is dephosphorylated to PI3P by FIG4 at the late endosome membrane

Stable Identifier
R-HSA-1676020
Type
Reaction [transition]
Species
Homo sapiens
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At the late endosome membrane, the PAS complex, consisting of FYVE finger-containing phosphoinositide kinase (PIKFYVE), yeast VAC14 homologue (VAC14), and polyphosphoinositide phosphatase aka SAC3 (FIG4), binds to the membrane via PIKFYVE's FYVE finger. The FIG4 phosphatase component dephosphorylates phosphatidylinositol 3,5-bisphosphate (PI(3,5)P2) to phosphatidylinositol 3-phosphate (PI3P) (Sbrissa et al. 2007, Sbrissa et al. 2008).

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Catalyst Activity
Title
phosphatidylinositol-3,5-bisphosphate 5-phosphatase activity of PIKFYVE:VAC14:FIG4 [late endosome membrane]
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