Reactome | CAD hexamer transforms L-Gln to CAP

CAD hexamer transforms L-Gln to CAP

Stable Identifier

R-HSA-73577

Type

Reaction [transition]

Species

Homo sapiens

Compartment

cytosol

Synonyms

L-glutamine + 2 ATP + HCO3- + H2O => carbamoyl phosphate + L-glutamate + 2 ADP + orthophosphate, bicarbonate and glutamine combine to form carbamoyl phosphate

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The synthesis of carbamoyl phosphate from glutamine, bicarbonate, and ATP is catalyzed by the carbamoyl-phosphate synthase (glutamine-hydrolyzing) activity of cytosolic trifunctional CAD (carbamoyl-phosphate synthetase 2, aspartate transcarbamylase, and dihydroorotase) protein (Ito and Uchino 1973; Iwahana et al. 1996). The purified human protein is active in several different oligomerization states, as is its Syrian hamster homologue. The most abundant form of the latter is a hexamer, and the active human protein is annotated as a hexamer by inference (Ito and Uchino 1973; Lee et al. 1985).

Literature References

PubMed ID	Title	Journal	Year
4684686	Control of pyrimidine biosynthesis in human lymphocytes. Simultaneous increase in activities of glutamine-utilizing carbamyl phosphate synthetase and aspartate transcarbamylase in phytohemagglutinin-stimulated human peripheral lymphocytes and their enzyme co-purification Ito, K, Uchino, H	J Biol Chem	1973
8619816	Molecular cloning of a human cDNA encoding a trifunctional enzyme of carbamoyl-phosphate synthetase-aspartate transcarbamoylase-dihydroorotase in de Novo pyrimidine synthesis Ii, S, Yoshimoto, K, Iwahana, H, Takahashi, Y, Itakura, M, Yamaoka, T, Kondo, M, Moritani, M, Fujimura, H	Biochem Biophys Res Commun	1996