inosine 5'-monophosphate + L-aspartate + GTP => adenylosuccinate + guanosine 5'-diphosphate + orthophosphate

Stable Identifier
R-MMU-111519
Type
Reaction [transition]
Species
Mus musculus
Compartment
ReviewStatus
5/5
General
SVG |   | PPTX  | SBGN
inosine 5'-monophosphate + L-aspartate + GTP => adenylosuccinate + guanosine  5'-diphosphate + orthophosphate

Cytosolic ADSS dimer catalyzes the reaction of inosine 5'-monophosphate (IMP), aspartate, and GTP to form adenylosuccinate, GDP, and orthophosphate (Borza et al. 2003; Guicherit et al. 1994).

Literature References
PubMed ID Title Journal Year
12482871 Variations in the response of mouse isozymes of adenylosuccinate synthetase to inhibitors of physiological relevance

Fromm, HJ, Pike, E, Honzatko, RB, Borza, T, Iancu, CV

J Biol Chem 2003
8308018 Amplification of an adenylosuccinate synthetase gene in alanosine-resistant murine T-lymphoma cells

Rudolph, FB, Kellems, RE, Guicherit, OM, Cooper, BF

J Biol Chem 1994
Participants
Catalyst Activity

adenylosuccinate synthase activity of Adenylosuccinate synthetase holoenzyme dimer [cytosol]

This event is regulated
Negatively by
Regulator