inosine 5'-monophosphate + L-aspartate + GTP => adenylosuccinate + guanosine 5'-diphosphate + orthophosphate

Stable Identifier
R-MMU-111519
Type
Reaction [transition]
Species
Mus musculus
Compartment
cytosol
ReviewStatus
5/5
General
SVG | 
PNG
Low
Medium
High
 | PPTX  | SBGN
inosine 5'-monophosphate + L-aspartate + GTP => adenylosuccinate + guanosine 5'-diphosphate + orthophosphate
Cytosolic ADSS dimer catalyzes the reaction of inosine 5'-monophosphate (IMP), aspartate, and GTP to form adenylosuccinate, GDP, and orthophosphate (Borza et al. 2003; Guicherit et al. 1994).
Literature References
PubMed ID Title Journal Year
12482871 Variations in the response of mouse isozymes of adenylosuccinate synthetase to inhibitors of physiological relevance

Borza, T, Iancu, CV, Pike, E, Honzatko, RB, Fromm, HJ

J Biol Chem 2003
8308018 Amplification of an adenylosuccinate synthetase gene in alanosine-resistant murine T-lymphoma cells

Guicherit, OM, Cooper, BF, Rudolph, FB, Kellems, RE

J Biol Chem 1994
Participants
Input
Output
Catalyst Activity

adenylosuccinate synthase activity of Adenylosuccinate synthetase holoenzyme dimer [cytosol]

Physical Entity
Adenylosuccinate synthetase holoenzyme dimer [cytosol] (Mus musculus)
Activity
adenylosuccinate synthase activity (GO:0004019)
This event is regulated
Negatively by
Regulator
GDP [cytosol]
Regulator
AMP [cytosol]
Regulator
F1,6PP [cytosol]
Regulator
ADS [cytosol]
Regulator
GMP [cytosol]
Orthologous Events
inosine 5'-monophosphate (IMP) + L-aspartate + GTP => adenylosuccinate + GDP + orthophosphate (Gallus gallus)
Created
D'Eustachio, P  (2004-02-18)
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