Adenylate cyclase increases the GTPase activity of Gi alpha

Stable Identifier
R-HSA-170686
Type
Reaction [transition]
Species
Homo sapiens
Compartment
plasma membrane, cytosol
ReviewStatus
5/5
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Adenylate cyclase increases the GTPase activity of Gi alpha
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G proteins can deactivate themselves via their intrinsic GTPase activity, which hydrolyzes GTP to GDP. Effectors such as adenylate cyclase can increase the G protein GTPase rate, acting like GTPase-activating proteins (GAPs).
Literature References
PubMed ID Title Journal Year
7937899 Mechanism of GTP hydrolysis by G-protein alpha subunits

Kleuss, C, Gilman, AG, Sprang, SR, Raw, AS, Lee, E

Proc Natl Acad Sci U S A 1994
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Output
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as an event of
Catalyst Activity

GTPase activity of (Gi alpha1:GTP:Adenylate cyclase):(G alpha-olf:GTP) [plasma membrane]

Physical Entity
(Gi alpha1:GTP:Adenylate cyclase):(G alpha-olf:GTP) [plasma membrane] (Homo sapiens)
Activity
GTPase activity (GO:0003924)
Orthologous Events
Adenylate cyclase increases the GTPase activity of Gi alpha (Bos taurus)
Adenylate cyclase increases the GTPase activity of Gi alpha (Caenorhabditis elegans)
Adenylate cyclase increases the GTPase activity of Gi alpha (Canis familiaris)
Adenylate cyclase increases the GTPase activity of Gi alpha (Danio rerio)
Adenylate cyclase increases the GTPase activity of Gi alpha (Dictyostelium discoideum)
Adenylate cyclase increases the GTPase activity of Gi alpha (Drosophila melanogaster)
Adenylate cyclase increases the GTPase activity of Gi alpha (Gallus gallus)
Adenylate cyclase increases the GTPase activity of Gi alpha (Mus musculus)
Adenylate cyclase increases the GTPase activity of Gi alpha (Rattus norvegicus)
Adenylate cyclase increases the GTPase activity of Gi alpha (Sus scrofa)
Adenylate cyclase increases the GTPase activity of Gi alpha (Xenopus tropicalis)
Authored
Jassal, B  (2004-03-31)
Le Novere, N  (2004-03-31)
Reviewed
Castagnoli, L  (2008-11-06)
Created
Jassal, B  (2006-01-10)
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