Adenylate cyclase increases the GTPase activity of Gi alpha

Stable Identifier
R-HSA-170686
Type
Reaction [transition]
Species
Homo sapiens
Compartment
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G proteins can deactivate themselves via their intrinsic GTPase activity, which hydrolyzes GTP to GDP. Effectors such as adenylate cyclase can increase the G protein GTPase rate, acting like GTPase-activating proteins (GAPs).

Literature References
PubMed ID Title Journal Year
7937899 Mechanism of GTP hydrolysis by G-protein alpha subunits

Kleuss, C, Raw, AS, Lee, E, Sprang, SR, Gilman, AG

Proc Natl Acad Sci U S A 1994
Participants
Participant Of
Catalyst Activity
Catalyst Activity
Title
GTPase activity of (Gi alpha1:GTP:Adenylate cyclase):(G alpha-olf:GTP) [plasma membrane]
Physical Entity
Activity
Orthologous Events
Authored
Reviewed
Created