G proteins can deactivate themselves via their intrinsic GTPase activity, which hydrolyzes GTP to GDP. Effectors such as adenylate cyclase can increase the G protein GTPase rate, acting like GTPase-activating proteins (GAPs).
Kleuss, C, Gilman, AG, Sprang, SR, Raw, AS, Lee, E
GTPase activity of (Gi alpha1:GTP:Adenylate cyclase):(G alpha-olf:GTP) [plasma membrane]
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