Reactome | PTPN6 dephosphorylates JAK3

PTPN6 dephosphorylates JAK3

Stable Identifier

R-HSA-9701507

Type

Reaction [transition]

Species

Homo sapiens

Compartment

cytosol

ReviewStatus

5/5

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PTPN6, also known as SHP1, dephosphorylates JAK3 downstream of ALK signaling, leading to the inactivation and increased proteolytic degradation of JAK3 (Han et al, 2006 a, b; reviewed in Palmer et al, 2009; Chiarle et al, 2008). PTPN6 gene expression is lost in some cases of anaplastic large cell lymphoma (ALCL) due to changes in promoter methylation, resulting in increased JAK3 activity in these cancers (Khoury et al, 2004; reviewed in Chiarle et al, 2008; Palmer et al, 2009).

Literature References

PubMed ID	Title	Journal	Year
19459784	Anaplastic lymphoma kinase: signalling in development and disease Grabbe, C, Vernersson, E, Palmer, RH, Hallberg, B	Biochem. J.	2009
15317731	Methylation of SHP1 gene and loss of SHP1 protein expression are frequent in systemic anaplastic large cell lymphoma Khoury, JD, Amin, HM, Rassidakis, GZ, Medeiros, LJ, Lai, R	Blood	2004
18097461	The anaplastic lymphoma kinase in the pathogenesis of cancer Chiarle, R, Piva, R, Ambrogio, C, Inghirami, G, Voena, C	Nat. Rev. Cancer	2008
16825495	Loss of SHP1 enhances JAK3/STAT3 signaling and decreases proteosome degradation of JAK3 and NPM-ALK in ALK+ anaplastic large-cell lymphoma Frantz, C, Amin, HM, Franko, B, Han, Y, Lai, R, Shi, X	Blood	2006
16871283	Restoration of shp1 expression by 5-AZA-2'-deoxycytidine is associated with downregulation of JAK3/STAT3 signaling in ALK-positive anaplastic large cell lymphoma Amin, HM, Franko, B, Frantz, C, Han, Y, Lai, R, Lin, Q, Lee, J	Leukemia	2006