NT5C3B hydrolyses 7MGP to 7MG

Stable Identifier
R-HSA-5694126
Type
Reaction
Species
Homo sapiens
Compartment
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Cytosolic 7-methylguanosine phosphate-specific 5'-nucleotidase (NT5C3B) specifically hydrolyses N(7)-methylguanosine monophosphate (7MGMP) to 7-methylguanosine (7MG) and inorganic phosphate (Pi). 7MGP is a modified nucleotide byproduct of mRNA turnover and requires degradation as its incorporation into nucleic acids is undesirable (Buschmann et al. 2013).

Literature References
PubMed ID Title Journal Year
23223233 Identification of Drosophila and human 7-methyl GMP-specific nucleotidases

Schierhorn, A, Lilie, H, Moritz, B, Wahle, E, Jeske, M, Buschmann, J

J. Biol. Chem. 2013
Participants
Participates
Catalyst Activity

5'-nucleotidase activity of NT5C3B [cytosol]

Orthologous Events
Cross References
Rhea
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