NT5C3B hydrolyses 7MGP to 7MG

Stable Identifier
R-HSA-5694126
Type
Reaction [transition]
Species
Homo sapiens
Compartment
cytosol
ReviewStatus
5/5
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NT5C3B hydrolyses 7MGP to 7MG
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Cytosolic 7-methylguanosine phosphate-specific 5'-nucleotidase (NT5C3B) specifically hydrolyses N(7)-methylguanosine monophosphate (7MGMP) to 7-methylguanosine (7MG) and inorganic phosphate (Pi). 7MGP is a modified nucleotide byproduct of mRNA turnover and requires degradation as its incorporation into nucleic acids is undesirable (Buschmann et al. 2013).
Literature References
PubMed ID Title Journal Year
23223233 Identification of Drosophila and human 7-methyl GMP-specific nucleotidases

Buschmann, J, Moritz, B, Jeske, M, Lilie, H, Schierhorn, A, Wahle, E

J. Biol. Chem. 2013
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Catalyst Activity

5'-nucleotidase activity of NT5C3B [cytosol]

Physical Entity
NT5C3B [cytosol] (Homo sapiens)
Activity
5'-nucleotidase activity (GO:0008253)
Orthologous Events
NT5C3B hydrolyses 7MGP to 7MG (Bos taurus)
NT5C3B hydrolyses 7MGP to 7MG (Caenorhabditis elegans)
NT5C3B hydrolyses 7MGP to 7MG (Canis familiaris)
NT5C3B hydrolyses 7MGP to 7MG (Drosophila melanogaster)
NT5C3B hydrolyses 7MGP to 7MG (Gallus gallus)
NT5C3B hydrolyses 7MGP to 7MG (Mus musculus)
NT5C3B hydrolyses 7MGP to 7MG (Rattus norvegicus)
NT5C3B hydrolyses 7MGP to 7MG (Sus scrofa)
NT5C3B hydrolyses 7MGP to 7MG (Xenopus tropicalis)
Cross References
RHEA
Authored
Jassal, B  (2015-05-21)
Reviewed
D'Eustachio, P  (2015-06-26)
Created
Jassal, B  (2015-05-21)
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