NT5C3B hydrolyses 7MGP to 7MG

Stable Identifier
R-HSA-5694126
Type
Reaction [transition]
Species
Homo sapiens
Compartment
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Cytosolic 7-methylguanosine phosphate-specific 5'-nucleotidase (NT5C3B) specifically hydrolyses N(7)-methylguanosine monophosphate (7MGMP) to 7-methylguanosine (7MG) and inorganic phosphate (Pi). 7MGP is a modified nucleotide byproduct of mRNA turnover and requires degradation as its incorporation into nucleic acids is undesirable (Buschmann et al. 2013).

Literature References
PubMed ID Title Journal Year
23223233 Identification of Drosophila and human 7-methyl GMP-specific nucleotidases

Buschmann, J, Moritz, B, Jeske, M, Lilie, H, Schierhorn, A, Wahle, E

J. Biol. Chem. 2013
Participants
Participant Of
Catalyst Activity
Catalyst Activity
Title
5'-nucleotidase activity of NT5C3B [cytosol]
Physical Entity
Activity
Orthologous Events
Cross References
Rhea
Authored
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Created