VPS4 mediates disassembly of ESCRTIII subunits to promote sealing of holes in the nuclear envelope

Stable Identifier
R-HSA-9668415
Type
Reaction [transition]
Species
Homo sapiens
Compartment
cytosol, nuclear envelope
ReviewStatus
5/5
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VPS4 mediates disassembly of ESCRTIII subunits to promote sealing of holes in the nuclear envelope
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The AAA+ ATPase action of VPS4 causes reorganization/disassembly of ESCRT-III filaments, which leads to membrane fusion and sealing of nuclear envelope holes (Vietri et al. 2015).
Literature References
PubMed ID Title Journal Year
26040712 Spastin and ESCRT-III coordinate mitotic spindle disassembly and nuclear envelope sealing

Vietri, M, Schink, KO, Campsteijn, C, Wegner, CS, Schultz, SW, Christ, L, Thoresen, SB, Brech, A, Raiborg, C, Stenmark, H

Nature 2015
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Catalyst Activity

ATP hydrolysis activity of LEM2D:ESCRT-III:IST1:CC2D1B:SPAST:VPS4A [nuclear envelope]

Physical Entity
LEM2D:ESCRT-III:IST1:CC2D1B:SPAST:VPS4A [nuclear envelope] (Homo sapiens)
Activity
ATP hydrolysis activity (GO:0016887)
Authored
Gerace, L  (2019-11-07)
Created
Orlic-Milacic, M  (2019-11-25)
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