VPS4 mediates disassembly of ESCRTIII subunits to promote sealing of holes in the nuclear envelope

Stable Identifier
R-HSA-9668415
Type
Reaction [transition]
Species
Homo sapiens
Compartment
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The AAA+ ATPase action of VPS4 causes reorganization/disassembly of ESCRT-III filaments, which leads to membrane fusion and sealing of nuclear envelope holes (Vietri et al. 2015).

Literature References
PubMed ID Title Journal Year
26040712 Spastin and ESCRT-III coordinate mitotic spindle disassembly and nuclear envelope sealing

Vietri, M, Schink, KO, Campsteijn, C, Wegner, CS, Schultz, SW, Christ, L, Thoresen, SB, Brech, A, Raiborg, C, Stenmark, H

Nature 2015
Participants
Participant Of
Catalyst Activity
Catalyst Activity
Title
ATPase activity of LEM2D:ESCRT-III:IST1:CC2D1B:SPAST:VPS4A [nuclear envelope]
Physical Entity
Activity
Orthologous Events
Authored
Created