VPS4 mediates disassembly of ESCRTIII subunits to promote sealing of holes in the nuclear envelope

Stable Identifier
R-HSA-9668415
Type
Reaction [transition]
Species
Homo sapiens
Compartment
cytosol, nuclear envelope
ReviewStatus
5/5
Locations in the PathwayBrowser
Expand all
General
SVG | 
PNG
Low
Medium
High
 | PPTX  | SBGN
VPS4 mediates disassembly of ESCRTIII subunits to promote sealing of holes in the nuclear envelope
Click the image above or here to open this reaction in the Pathway Browser
The layout of this reaction may differ from that in the pathway view due to the constraints in pathway layout
The AAA+ ATPase action of VPS4 causes reorganization/disassembly of ESCRT-III filaments, which leads to membrane fusion and sealing of nuclear envelope holes (Vietri et al. 2015).
Literature References
PubMed ID Title Journal Year
26040712 Spastin and ESCRT-III coordinate mitotic spindle disassembly and nuclear envelope sealing

Campsteijn, C, Schultz, SW, Schink, KO, Wegner, CS, Brech, A, Christ, L, Raiborg, C, Thoresen, SB, Stenmark, H, Vietri, M

Nature 2015
Participants
Input
Output
Participates
as an event of
Catalyst Activity

ATP hydrolysis activity of LEM2D:ESCRT-III:IST1:CC2D1B:SPAST:VPS4A [nuclear envelope]

Physical Entity
LEM2D:ESCRT-III:IST1:CC2D1B:SPAST:VPS4A [nuclear envelope] (Homo sapiens)
Activity
ATP hydrolysis activity (GO:0016887)
Authored
Gerace, L  (2019-11-07)
Created
Orlic-Milacic, M  (2019-11-25)
Cite Us!