Inactivation of PLC beta

Stable Identifier
R-HSA-112037
Type
Reaction [dissociation]
Species
Homo sapiens
Compartment
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PLC-beta1 is a GTPase-activating protein (GAP) for Gq-alpha, exchanging GTP for GDP and releasing the alpha subunit to cycle back to the membrane and reassociate with the beta-gamma subunits. Between itself and the receptor, they regulate the amplitude of the PLC signal and the rates of signal initiation and termination.

Literature References
PubMed ID Title Journal Year
1322796 Phospholipase C-beta 1 is a GTPase-activating protein for Gq/11, its physiologic regulator

Berstein, G, Blank, JL, Jhon, DY, Exton, JH, Rhee, SG, Ross, EM

Cell 1992
Participants
Participant Of
Orthologous Events
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