RHOA GAPs stimulate RHOA GTPase activity

Stable Identifier
R-HSA-8981637
Type
Reaction [transition]
Species
Homo sapiens
Compartment
Locations in the PathwayBrowser
General
SVG |   | PPTX  | SBGN
Click the image above or here to open this reaction in the Pathway Browser
The layout of this reaction may differ from that in the pathway view due to the constraints in pathway layout

The following GTPase activating proteins (GAPs) were shown to bind RHOA and stimulate its GTPase activity, resulting in GTP to GDP hydrolysis and conversion of the active RHOA:GTP complex into the inactive RHOA:GDP complex (the high throughput study by Bagci et al. 2020 looked at preferential binding of GAPs to active RHOA mutant compared to wild type RHOA but did not examine activation of GTPase activity):
ARHGAP5 (Burbelo et al. 1995; Kusama et al. 2006; Amin et al. 2016; Müller et al. 2020; supported by Bagci et al. 2020)
ARHGAP6 (Prakash et al. 2000; Müller et al. 2020)
ARHGAP8 (Lua and Low 2004; Müller et al. 2020)
ARHGAP10 (Shibata et al. 2001; Müller et al. 2020)
ARHGAP11A (Lawson et al. 2016; Müller et al. 2020)
ARHGAP11B (Müller et al. 2020)
ARHGAP19 (David et al. 2014; Müller et al. 2020)
ARHGAP20 (Müller et al. 2020)
ARHGAP21 (Sousa et al. 2005; Lazarini et al. 2013; Müller et al. 2020; supported by Bagci et al. 2020)
ARHGAP23 (Müller et al. 2020)
ARHGAP26 (Hildebrand et al. 1996; Sheffield et al. 1999; Amin et al. 2016; Müller et al. 2020)
ARHGAP28 (Yeung et al. 2014; Müller et al. 2020)
ARHGAP29 (Saras et al. 1997; Müller et al. 2020; supported by Bagci et al. 2020)
ARHGAP30 (Naji et al. 2011; Müller et al. 2020)
ARHGAP40 (Müller et al. 2020)
DLC1 (Healy et al. 2008; Amin et al. 2016; Müller et al. 2020)
GMIP (Aresta et al. 2002; Müller et al. 2020)
HMHA1 (de Kreuk et al. 2013)
MYO9A (Handa et al. 2013; Omelchenko and Hall 2012; Müller et al. 2020; supported by Bagci et al. 2020)
MYO9B (Post et al. 1998; Graf et al. 2000; Kong et al. 2015; Müller et al. 2020; supported by Bagci et al. 2020)
TAGAP (Bauer et al. 2005; Müller et al. 2020)

The following GAPs were shown to bind RHOA and stimulate its GTPase activity in some but not all studies and are annotated as candidate RHOA GAPs:
ABR (Bagci et al. 2020: binding to active RHOA; Chuang et al. 1995, Amin et al. 2016, Müller et al. 2020: no activation of RHOA GTPase activity)
ARAP1 (Miura et al. 2002: activation of RHOA GTPase activity; Müller et al. 2020: no activation of RHOA GTPase activity)
ARAP2 (Müller et al. 2020: activation of RHOA GTPase activity; Yoon et al. 2006: no activation of RHOA GTPase activity; Bagci et al. 2020: no binding to active RHOA)
ARAP3 (Krugmann et al. 2002: activation of RHOA GTPase activity; Müller et al. 2020: no activation of RHOA GTPase activity; Bagci et al. 2020: no binding to active RHOA)
ARHGAP1 (Zhang and Zheng 1998, Amin et al. 2016, Müller et al. 2020: activation of RHOA GTPase activity; Bagci et al. 2020: binding to active RHOA; Yang et al. 2006, Li et al. 2009: no activation of RHOA GTPase activity)
ARHGAP4 (Vogt et al. 2007: activation of RHOA GTPase activity; Müller et al. 2020: no activation of RHOA GTPase activity)
ARHGAP9 (Furukawa et al. 2001: activation of RHOA GTPase activity; Müller et al. 2020: no activation of RHOA GTPase activity)
ARHGAP18 (Maeda et al. 2011: activation of RHOA GTPase activity; Müller et al. 2020: no activation of RHOA GTPase activity)
ARHGAP22 (Müller et al. 2020: activation of RHOA GTPase activity; Mori et al. 2014: no activation of RHOA GTPase activity)
ARHGAP24 (Su et al. 2004: activation of RHOA GTPase activity; Lavelin and Geiger 2005, Ohta et al. 2006, Müller et al. 2020: no activation of RHOA GTPase activity)
ARHGAP31 (Müller et al. 2020: activation of RHOA GTPase activity; Tcherkezian et al. 2006: no activation of RHOA GTPase activity; Bagci et al. 2020: no binding to active RHOA)
ARHGAP32 (Nakazawa et al. 2003: activation of RHOA GTPase activity; Bagci et al. 2020: binding to active RHOA; Müller et al. 2020: no activation of RHOA GTPase activity)
ARHGAP35 (Levay et al. 2009, Amin et al. 2016; Müller et al. 2020: activation of RHOA GTPase activity; Bagci et al. 2020: no binding to active RHOA)
ARHGAP39 (Bagci et al. 2020: binding to active RHOA; Lundstrom et al. 2004, Müller et al. 2020: no activation of RHOA GTPase activity)
ARHGAP42 (Bai et al. 2013, Luo et al. 2017, Bai et al. 2017: activation of RHOA GTPase activity; Bagci et al. 2020: no binding to active RHOA)
ARHGAP44 (Raynaud et al. 2014: activation of RHOA GTPase activity; Müller et al. 2020: no activation of RHOA GTPase activity)
BCR (Zhang and Zheng 1998: activation of RHOA GTPase activity; Bagci et al. 2020: binding to active RHOA; Chuang et al. 1995, Müller et al. 2020: no activation of RHOA GTPase activity),
DEPDC1B (Bagci et al. 2020: binding to active RHOA; Wu et al. 2015, Müller et al. 2020: no activation of RHOA GTPase activity)
FAM13A (Li et al. 2015: activation of RHOA GTPase activity; Müller et al. 2020: no activation of RHOA GTPase activity)
OPHN1 (Elvers et al. 2012, Amin et al. 2016: activation of RHOA GTPase activity; Müller et al. 2020: no activation of RHOA GTPase activity; Bagci et al. 2020: no binding to active RHOA)
PIK3R1 (Bagci et al. 2020: binding to active RHOA; Müller et al. 2020: no activation of RHOA GTPase activity)
PIK3R2 (Bagci et al. 2020: binding to active RHOA; Müller et al. 2020: no activation of RHOA GTPase activity)
RACGAP1 (Toure et al. 1998; Amin et al. 2016: activation of RHOA GTPase activity; Müller et al. 2020: no activation of RHOA GTPase activity; Bagci et al. 2020: no binding to active RHOA)
SRGAP1 (Wong et al. 2001: activation of RHOA GTPase activity; Müller et al. 2020: no activation of RHOA GTPase activity)
STARD8 (Kawai et al. 2007, Müller et al. 2020: activation of RHOA GTPase activity; Amin et al. 2016: no activation of RHOA GTPase activity)
STARD13 (Ching et al. 2003, Leung et al. 2005, Müller et al. 2020: activation of RHOA GTPase activity; Amin et al. 2016: no activation of RHOA GTPase activity)

The following GAPs do not act on RHOA or were shown to not bind to active RHOA without testing for activation of RHOA GTPase activity:
ARHGAP12 (Müller et al. 2020; Bagci et al. 2020: no binding to RHOA)
ARHGAP15 (Seoh et al. 2003; Müller et al. 2020)
ARHGAP17 (Richnau and Aspenstrom 2001; Amin et al. 2016; Müller et al. 2020; Bagci et al. 2020: no binding to RHOA)
ARHGAP25 (Csepanyi Komi et al. 2012; Müller et al. 2020)
ARHGAP27 (Sakakibara et al. 2004; Müller et al. 2020)
ARHGAP33 (Liu et al. 2006; Müller et al. 2020)
ARHGAP36 (Müller et al. 2020)
ARHGAP45 (Müller et al. 2020)
CHN1 (Ahmed et al. 1994; Müller et al. 2020)
CHN2 (Caloca et al. 2003; Müller et al. 2020)
DEPDC1 (Müller et al. 2020)
FAM13B (Müller et al. 2020)
INPP5B (Müller et al. 2020)
OCRL (Lichter Konecki et al. 2006; Erdmann et al. 2007; Müller et al. 2020; Bagci et al. 2020: no binding to active RHOA)
RALBP1 (Jullien Flores et al. 1995; Müller et al. 2020)
SH3BP1 (Müller et al. 2020)
SRGAP2 (Mason et al. 2011; Müller et al. 2020; Bagci et al. 2020: no binding to active RHOA)
SRGAP3 (Endris et al. 2002; Müller et al. 2020)
SYDE1 (Müller et al. 2020; Bagci et al. 2020: no binding to active RHOA)
SYDE2 (Müller et al. 2020)

Literature References
PubMed ID Title Journal Year
15342493 Vilse, a conserved Rac/Cdc42 GAP mediating Robo repulsion in tracheal cells and axons

Lundström, A, Gallio, M, Englund, C, Steneberg, P, Hemphälä, J, Aspenström, P, Keleman, K, Falileeva, L, Dickson, BJ, Samakovlis, C

Genes Dev 2004
27216196 Rho GTPase Transcriptome Analysis Reveals Oncogenic Roles for Rho GTPase-Activating Proteins in Basal-like Breast Cancers

Lawson, CD, Fan, C, Mitin, N, Baker, NM, George, SD, Graham, DM, Perou, CM, Burridge, K, Der, CJ, Rossman, KL

Cancer Res. 2016
23870313 Vaccinia virus F11 promotes viral spread by acting as a PDZ-containing scaffolding protein to bind myosin-9A and inhibit RhoA signaling

Handa, Y, Durkin, CH, Dodding, MP, Way, M

Cell Host Microbe 2013
21865595 ARHGAP18, a GTPase-activating protein for RhoA, controls cell shape, spreading, and motility

Maeda, M, Hasegawa, H, Hyodo, T, Ito, S, Asano, E, Yuang, H, Funasaka, K, Shimokata, K, Hasegawa, Y, Hamaguchi, M, Senga, T

Mol. Biol. Cell 2011
26529257 Myo9b is a key player in SLIT/ROBO-mediated lung tumor suppression

Kong, R, Yi, F, Wen, P, Liu, J, Chen, X, Ren, J, Li, X, Shang, Y, Nie, Y, Wu, K, Fan, D, Zhu, L, Feng, W, Wu, JY

J. Clin. Invest. 2015
11396949 Isolation of a novel human gene, ARHGAP9, encoding a rho-GTPase activating protein

Furukawa, Y, Kawasoe, T, Daigo, Y, Nishiwaki, T, Ishiguro, H, Takahashi, M, Kitayama, J, Nakamura, Y

Biochem. Biophys. Res. Commun. 2001
10699171 Functional analysis of ARHGAP6, a novel GTPase-activating protein for RhoA

Prakash, SK, Paylor, R, Jenna, S, Lamarche-Vane, N, Armstrong, DL, Xu, B, Mancini, MA, Zoghbi, HY

Hum. Mol. Genet. 2000
11432776 PKNbeta interacts with the SH3 domains of Graf and a novel Graf related protein, Graf2, which are GTPase activating proteins for Rho family

Shibata, H, Oishi, K, Yamagiwa, A, Matsumoto, M, Mukai, H, Ono, Y

J. Biochem. 2001
25704760 Identification of the GTPase-activating protein DEP domain containing 1B (DEPDC1B) as a transcriptional target of Pitx2

Wu, D, Zhu, X, Jimenez-Cowell, K, Mold, AJ, Sollecito, CC, Lombana, N, Jiao, M, Wei, Q

Exp. Cell Res. 2015
22298643 The GRAF family member oligophrenin1 is a RhoGAP with BAR domain and regulates Rho GTPases in platelets

Elvers, M, Beck, S, Fotinos, A, Ziegler, M, Gawaz, M

Cardiovasc. Res. 2012
22305756 Myosin-IXA regulates collective epithelial cell migration by targeting RhoGAP activity to cell-cell junctions

Omelchenko, T, Hall, A

Curr. Biol. 2012
16116428 The t complex-encoded GTPase-activating protein Tagap1 acts as a transmission ratio distorter in mice

Bauer, H, Willert, J, Koschorz, B, Herrmann, BG

Nat. Genet. 2005
31871319 Mapping the proximity interaction network of the Rho-family GTPases reveals signalling pathways and regulatory mechanisms

Bagci, H, Sriskandarajah, N, Robert, A, Boulais, J, Elkholi, IE, Tran, V, Lin, ZY, Thibault, MP, Dubé, N, Faubert, D, Hipfner, DR, Gingras, AC, Cote, JF

Nat. Cell Biol. 2020
24259668 The RhoGAP ARHGAP19 controls cytokinesis and chromosome segregation in T lymphocytes

David, MD, Petit, D, Bertoglio, J

J. Cell. Sci. 2014
17932950 DLC-1 suppresses non-small cell lung cancer growth and invasion by RhoGAP-dependent and independent mechanisms

Healy, KD, Hodgson, L, Kim, TY, Shutes, A, Maddileti, S, Juliano, RL, Hahn, KM, Harden, TK, Bang, YJ, Der, CJ

Mol. Carcinog. 2008
12093360 A novel Rho GTPase-activating-protein interacts with Gem, a member of the Ras superfamily of GTPases

Aresta, S, de Tand-Heim, MF, Béranger, F, de Gunzburg, J

Biochem. J. 2002
28112683 Blood pressure-associated polymorphism controls ARHGAP42 expression via serum response factor DNA binding

Bai, X, Mangum, KD, Dee, RA, Stouffer, GA, Lee, CR, Oni-Orisan, A, Patterson, C, Schisler, JC, Viera, AJ, Taylor, JM, Mack, CP

J. Clin. Invest. 2017
21148482 Bi-modal regulation of a formin by srGAP2

Mason, FM, Heimsath, EG, Higgs, HN, Soderling, SH

J. Biol. Chem. 2011
7673236 Bridging Ral GTPase to Rho pathways. RLIP76, a Ral effector with CDC42/Rac GTPase-activating protein activity

Jullien-Flores, V, Dorseuil, O, Romero, F, Letourneur, F, Saragosti, S, Berger, R, Tavitian, A, Gacon, G, Camonis, JH

J. Biol. Chem. 1995
9490638 Human myosin-IXb is a mechanochemically active motor and a GAP for rho

Post, PL, Bokoch, GM, Mooseker, MS

J. Cell. Sci. 1998
16777452 The effect of missense mutations in the RhoGAP-homology domain on ocrl1 function

Lichter-Konecki, U, Farber, LW, Cronin, JS, Suchy, SF, Nussbaum, RL

Mol. Genet. Metab. 2006
19673492 Regulation of the substrate preference of p190RhoGAP by protein kinase C-mediated phosphorylation of a phospholipid binding site

Lévay, M, Settleman, J, Ligeti, E

Biochemistry 2009
11207612 Functional role for the class IX myosin myr5 in epithelial cell infection by Shigella flexneri

Graf, B, Bähler, M, Hilpelä, P, Böwe, C, Adam, T

Cell. Microbiol. 2000
16776779 Inactivation of Rho GTPases by p190 RhoGAP reduces human pancreatic cancer cell invasion and metastasis

Kusama, T, Mukai, M, Endo, H, Ishikawa, O, Tatsuta, M, Nakamura, H, Inoue, M

Cancer Sci. 2006
12877655 Characterization of the Rac-GAP (Rac-GTPase-activating protein) activity of beta2-chimaerin, a 'non-protein kinase C' phorbol ester receptor

Caloca, MJ, Wang, H, Kazanietz, MG

Biochem. J. 2003
24335996 The smooth muscle-selective RhoGAP GRAF3 is a critical regulator of vascular tone and hypertension

Bai, X, Lenhart, KC, Bird, KE, Suen, AA, Rojas, M, Kakoki, M, Li, F, Smithies, O, Mack, CP, Taylor, JM

Nat Commun 2013
16217026 Deleted in liver cancer 2 (DLC2) suppresses cell transformation by means of inhibition of RhoA activity

Leung, TH, Ching, YP, Yam, JW, Wong, CM, Yau, TO, Jin, DY, Ng, IO

Proc. Natl. Acad. Sci. U.S.A. 2005
9497316 MgcRacGAP, a new human GTPase-activating protein for Rac and Cdc42 similar to Drosophila rotundRacGAP gene product, is expressed in male germ cells

Touré, A, Dorseuil, O, Morin, L, Timmons, P, Jégou, B, Reibel, L, Gacon, G

J. Biol. Chem. 1998
17765681 A role of the Lowe syndrome protein OCRL in early steps of the endocytic pathway

Erdmann, KS, Mao, Y, McCrea, HJ, Zoncu, R, Lee, S, Paradise, S, Modregger, J, Biemesderfer, D, Toomre, D, De Camilli, P

Dev. Cell 2007
12650940 ArhGAP15, a novel human RacGAP protein with GTPase binding property

Seoh, ML, Ng, CH, Yong, J, Lim, L, Leung, T

FEBS Lett. 2003
11804590 ARAP1: a point of convergence for Arf and Rho signaling

Miura, K, Jacques, KM, Stauffer, S, Kubosaki, A, Zhu, K, Hirsch, DS, Resau, J, Zheng, Y, Randazzo, PA

Mol. Cell 2002
23200924 ARHGAP21 is a RhoGAP for RhoA and RhoC with a role in proliferation and migration of prostate adenocarcinoma cells

Lazarini, M, Traina, F, Machado-Neto, JA, Barcellos, KS, Moreira, YB, Brandão, MM, Verjovski-Almeida, S, Ridley, AJ, Saad, ST

Biochim. Biophys. Acta 2013
10232922 Expression, purification and crystallization of a BH domain from the GTPase regulatory protein associated with focal adhesion kinase

Sheffield, PJ, Derewenda, U, Taylor, J, Parsons, TJ, Derewenda, ZS

Acta Crystallogr. D Biol. Crystallogr. 1999
8649427 An SH3 domain-containing GTPase-activating protein for Rho and Cdc42 associates with focal adhesion kinase

Hildebrand, JD, Taylor, JM, Parsons, JT

Mol. Cell. Biol. 1996
16184169 ARHGAP10 is necessary for alpha-catenin recruitment at adherens junctions and for Listeria invasion

Sousa, S, Cabanes, D, Archambaud, C, Colland, F, Lemichez, E, Popoff, M, Boisson-Dupuis, S, Gouin, E, Lecuit, M, Legrain, P, Cossart, P

Nat. Cell Biol. 2005
27481945 Deciphering the Molecular and Functional Basis of RHOGAP Family Proteins: A SYSTEMATIC APPROACH TOWARD SELECTIVE INACTIVATION OF RHO FAMILY PROTEINS

Amin, E, Jaiswal, M, Derewenda, U, Reis, K, Nouri, K, Koessmeier, KT, Aspenström, P, Somlyo, AV, Dvorsky, R, Ahmadian, MR

J. Biol. Chem. 2016
17976533 START-GAP3/DLC3 is a GAP for RhoA and Cdc42 and is localized in focal adhesions regulating cell morphology

Kawai, K, Kiyota, M, Seike, J, Deki, Y, Yagisawa, H

Biochem. Biophys. Res. Commun. 2007
12531887 Deleted in liver cancer (DLC) 2 encodes a RhoGAP protein with growth suppressor function and is underexpressed in hepatocellular carcinoma

Ching, YP, Wong, CM, Chan, SF, Leung, TH, Ng, DC, Jin, DY, Ng, IO

J. Biol. Chem. 2003
9548756 Regulation of RhoA GTP hydrolysis by the GTPase-activating proteins p190, p50RhoGAP, Bcr, and 3BP-1

Zhang, B, Zheng, Y

Biochemistry 1998
16777849 Physical and functional interaction of Fyn tyrosine kinase with a brain-enriched Rho GTPase-activating protein TCGAP

Liu, H, Nakazawa, T, Tezuka, T, Yamamoto, T

J. Biol. Chem. 2006
16914516 Gene targeting of Cdc42 and Cdc42GAP affirms the critical involvement of Cdc42 in filopodia induction, directed migration, and proliferation in primary mouse embryonic fibroblasts

Yang, L, Wang, L, Zheng, Y

Mol. Biol. Cell 2006
11672528 Signal transduction in neuronal migration: roles of GTPase activating proteins and the small GTPase Cdc42 in the Slit-Robo pathway

Wong, K, Ren, XR, Huang, YZ, Xie, Y, Liu, G, Saito, H, Tang, H, Wen, L, Brady-Kalnay, SM, Mei, L, Wu, JY, Xiong, WC, Rao, Y

Cell 2001
9305890 A novel GTPase-activating protein for Rho interacts with a PDZ domain of the protein-tyrosine phosphatase PTPL1

Saras, J, Franzén, P, Aspenström, P, Hellman, U, Gonez, LJ, Heldin, CH

J. Biol. Chem. 1997
32203420 Systems analysis of RhoGEF and RhoGAP regulatory proteins reveals spatially organized RAC1 signalling from integrin adhesions

Müller, PM, Rademacher, J, Bagshaw, RD, Wortmann, C, Barth, C, van Unen, J, Alp, KM, Giudice, G, Eccles, RL, Heinrich, LE, Pascual-Vargas, P, Sanchez-Castro, M, Brandenburg, L, Mbamalu, G, Tucholska, M, Spatt, L, Czajkowski, MT, Welke, RW, Zhang, S, Nguyen, V, Rrustemi, T, Trnka, P, Freitag, K, Larsen, B, Popp, O, Mertins, P, Gingras, AC, Roth, FP, Colwill, K, Bakal, C, Pertz, O, Pawson, T, Petsalaki, E, Rocks, O

Nat Cell Biol 2020
8021274 Breakpoint cluster region gene product-related domain of n-chimaerin. Discrimination between Rac-binding and GTPase-activating residues by mutational analysis

Ahmed, S, Lee, J, Wen, LP, Zhao, Z, Ho, J, Best, A, Kozma, R, Lim, L

J. Biol. Chem. 1994
8537347 p190-B, a new member of the Rho GAP family, and Rho are induced to cluster after integrin cross-linking

Burbelo, PD, Miyamoto, S, Utani, A, Brill, S, Yamada, KM, Hall, A, Yamada, Y

J. Biol. Chem. 1995
28584191 ARHGAP42 is activated by Src-mediated tyrosine phosphorylation to promote cell motility

Luo, W, Janoštiak, R, Tolde, O, Ryzhova, LM, Koudelková, L, Dibus, M, Brábek, J, Hanks, SK, Rosel, D

J. Cell. Sci. 2017
17077126 ARAP2 effects on the actin cytoskeleton are dependent on Arf6-specific GTPase-activating-protein activity and binding to RhoA-GTP

Yoon, HY, Miura, K, Cuthbert, EJ, Davis, KK, Ahvazi, B, Casanova, JE, Randazzo, PA

J. Cell. Sci. 2006
12857875 p250GAP, a novel brain-enriched GTPase-activating protein for Rho family GTPases, is involved in the N-methyl-d-aspartate receptor signaling

Nakazawa, T, Watabe, AM, Tezuka, T, Yoshida, Y, Yokoyama, K, Umemori, H, Inoue, A, Okabe, S, Manabe, T, Yamamoto, T

Mol. Biol. Cell 2003
16862148 FilGAP, a Rho- and ROCK-regulated GAP for Rac binds filamin A to control actin remodelling

Ohta, Y, Hartwig, JH, Stossel, TP

Nat. Cell Biol. 2006
19494238 Cdc42GAP, reactive oxygen species, and the vimentin network

Li, QF, Spinelli, AM, Tang, DD

Am. J. Physiol., Cell Physiol. 2009
25211221 Arhgap28 is a RhoGAP that inactivates RhoA and downregulates stress fibers

Yeung, CY, Taylor, SH, Garva, R, Holmes, DF, Zeef, LA, Soininen, R, Boot-Handford, RP, Kadler, KE

PLoS ONE 2014
21565175 ARHGAP30 is a Wrch-1-interacting protein involved in actin dynamics and cell adhesion

Naji, L, Pacholsky, D, Aspenström, P

Biochem. Biophys. Res. Commun. 2011
7479768 Abr and Bcr are multifunctional regulators of the Rho GTP-binding protein family

Chuang, TH, Xu, X, Kaartinen, V, Heisterkamp, N, Groffen, J, Bokoch, GM

Proc. Natl. Acad. Sci. U.S.A. 1995
24933155 ARHGAP22 localizes at endosomes and regulates actin cytoskeleton

Mori, M, Saito, K, Ohta, Y

PLoS ONE 2014
15611138 Characterization of a novel GTPase-activating protein associated with focal adhesions and the actin cytoskeleton

Lavelin, I, Geiger, B

J. Biol. Chem. 2005
24352656 Rho-GTPase-activating protein interacting with Cdc-42-interacting protein 4 homolog 2 (Rich2): a new Ras-related C3 botulinum toxin substrate 1 (Rac1) GTPase-activating protein that controls dendritic spine morphogenesis

Raynaud, F, Moutin, E, Schmidt, S, Dahl, J, Bertaso, F, Boeckers, TM, Homburger, V, Fagni, L

J. Biol. Chem. 2014
15302923 A vascular cell-restricted RhoGAP, p73RhoGAP, is a key regulator of angiogenesis

Su, ZJ, Hahn, CN, Goodall, GJ, Reck, NM, Leske, AF, Davy, A, Kremmidiotis, G, Vadas, MA, Gamble, JR

Proc. Natl. Acad. Sci. U.S.A. 2004
22096251 ARHGAP25, a novel Rac GTPase-activating protein, regulates phagocytosis in human neutrophilic granulocytes

Csépányi-Kömi, R, Sirokmány, G, Geiszt, M, Ligeti, E

Blood 2012
17804252 ARHGAP4 is a novel RhoGAP that mediates inhibition of cell motility and axon outgrowth

Vogt, DL, Gray, CD, Young, WS, Orellana, SA, Malouf, AT

Mol. Cell. Neurosci. 2007
16519628 The human orthologue of CdGAP is a phosphoprotein and a GTPase-activating protein for Cdc42 and Rac1 but not RhoA

Tcherkezian, J, Triki, I, Stenne, R, Danek, EI, Lamarche-Vane, N

Biol. Cell 2006
24086303 The human minor histocompatibility antigen 1 is a RhoGAP

de Kreuk, BJ, Schaefer, A, Anthony, EC, Tol, S, Fernandez-Borja, M, Geerts, D, Pool, J, Hambach, L, Goulmy, E, Hordijk, PL

PLoS ONE 2013
26371245 Annexin A2 Regulates Autophagy in Pseudomonas aeruginosa Infection through the Akt1-mTOR-ULK1/2 Signaling Pathway

Li, R, Tan, S, Yu, M, Jundt, MC, Zhang, S, Wu, M

J. Immunol. 2015
12195014 The novel Rho-GTPase activating gene MEGAP/ srGAP3 has a putative role in severe mental retardation

Endris, V, Wogatzky, B, Leimer, U, Bartsch, D, Zatyka, M, Latif, F, Maher, ER, Tariverdian, G, Kirsch, S, Karch, D, Rappold, GA

Proc. Natl. Acad. Sci. U.S.A. 2002
15064355 BPGAP1 interacts with cortactin and facilitates its translocation to cell periphery for enhanced cell migration

Lua, BL, Low, BC

Mol. Biol. Cell 2004
11431473 Rich, a rho GTPase-activating protein domain-containing protein involved in signaling by Cdc42 and Rac1

Richnau, N, Aspenstrom, P

J Biol Chem 2001
11804589 Identification of ARAP3, a novel PI3K effector regulating both Arf and Rho GTPases, by selective capture on phosphoinositide affinity matrices

Krugmann, S, Anderson, KE, Ridley, SH, Risso, N, McGregor, A, Coadwell, J, Davidson, K, Eguinoa, A, Ellson, CD, Lipp, P, Manifava, M, Ktistakis, N, Painter, G, Thuring, JW, Cooper, MA, Lim, ZY, Holmes, AB, Dove, SK, Michell, RH, Grewal, A, Nazarian, A, Erdjument-Bromage, H, Tempst, P, Stephens, LR, Hawkins, PT

Mol Cell 2002
Participants
Participates
Catalyst Activity

GTPase activator activity of RHOA GAPs [cytosol]

Orthologous Events
Authored
Reviewed
Created
Cite Us!