Reactome | NANP dephosphorylates Neu5Ac-9-P to Neu5Ac

NANP dephosphorylates Neu5Ac-9-P to Neu5Ac

Stable Identifier

R-HSA-4084989

Type

Reaction

Species

Homo sapiens

Compartment

cytosol

Locations in the PathwayBrowser

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Metabolism of proteins (Homo sapiens)

- Post-translational protein modification (Homo sapiens)
  - Asparagine N-linked glycosylation (Homo sapiens)
    - Biosynthesis of the N-glycan precursor (dolichol lipid-linked oligosaccharide, LLO) and transfer to a nascent protein (Homo sapiens)
      - Synthesis of substrates in N-glycan biosythesis (Homo sapiens)
        
        Sialic acid metabolism (Homo sapiens)
        
        NANP dephosphorylates Neu5Ac-9-P to Neu5Ac (Homo sapiens)

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NANP dephosphorylates Neu5Ac-9-P to Neu5Ac

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N-acylneuraminate 9-phosphatase (NANP) dephosphorylates N-acetylneuraminate -9-phosphate (Neu5Ac-9-P) to produce N-acetylneuraminate (Neu5Ac). NANP requires Mg²⁺ as a cofactor (Maliekal et al. 2006).

Literature References

PubMed ID	Title	Journal	Year
16237198	Identification of the sequence encoding N-acetylneuraminate-9-phosphate phosphatase Maliekal, P, Delpierre, G, Vertommen, D, Van Schaftingen, E	Glycobiology	2006