Reactome | NANP dephosphorylates Neu5Ac-9-P to Neu5Ac

NANP dephosphorylates Neu5Ac-9-P to Neu5Ac

Stable Identifier

R-HSA-4084989

Type

Reaction [transition]

Species

Homo sapiens

Compartment

cytosol

Locations in the PathwayBrowser

Expand all

Metabolism of proteins (Homo sapiens)

- Post-translational protein modification (Homo sapiens)
  - Asparagine N-linked glycosylation (Homo sapiens)
    - Biosynthesis of the N-glycan precursor (dolichol lipid-linked oligosaccharide, LLO) and transfer to a nascent protein (Homo sapiens)
      - Synthesis of substrates in N-glycan biosythesis (Homo sapiens)
        
        Sialic acid metabolism (Homo sapiens)
        
        NANP dephosphorylates Neu5Ac-9-P to Neu5Ac (Homo sapiens)

General

SBML | | PDF

SVG | | PPTX | SBGN

NANP dephosphorylates Neu5Ac-9-P to Neu5Ac

Click the image above or here to open this reaction in the Pathway Browser
The layout of this reaction may differ from that in the pathway view due to the constraints in pathway layout

N-acylneuraminate 9-phosphatase (NANP) dephosphorylates N-acetylneuraminate -9-phosphate (Neu5Ac-9-P) to produce N-acetylneuraminate (Neu5Ac). NANP requires Mg²⁺ as a cofactor (Maliekal et al. 2006).

Literature References

PubMed ID	Title	Journal	Year
16237198	Identification of the sequence encoding N-acetylneuraminate-9-phosphate phosphatase Maliekal, P, Vertommen, D, Delpierre, G, Van Schaftingen, E	Glycobiology	2006