TTL ligates L-Tyr to the carboxy terminus of detyr-alpha tubulin:beta tubulin

Stable Identifier
Reaction [transition]
Homo sapiens
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TTL (tubulin tyrosine ligase) ligates tyrosine (L-Tyr) to the carboxy terminus of the alpha-tubulin subunit of an alpha tubulin:beta tubulin dimer in an ATP-dependent reaction. Human TTL has not been characterized in detail; the reaction mechanism annotated here has been worked out with bovine proteins (Deans et al. 1992), and structural studies with chicken proteins demonstrate the basis of the enzyme's specificity for the carboxy terminus of tubulin alpha chains (Prota et al. 2013).

Literature References
PubMed ID Title Journal Year
23358242 Structural basis of tubulin tyrosination by tubulin tyrosine ligase

Steinmetz, MO, Kammerer, RA, Jaussi, R, Kuijpers, M, Magiera, MM, Prota, AE, Bargsten, K, Hoogenraad, CC, Janke, C, Wieser, M, Frey, D

J. Cell Biol. 2013
1520276 Steady-state kinetic mechanism of bovine brain tubulin: tyrosine ligase

Allison, RD, Deans, NL, Purich, DL

Biochem. J. 1992
Catalyst Activity

tubulin-tyrosine ligase activity of TTL [cytosol]

Inferred From
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