TTL ligates L-Tyr to the carboxy terminus of detyr-alpha tubulin:beta tubulin

Stable Identifier
R-HSA-8955706
Type
Reaction [transition]
Species
Homo sapiens
Compartment
cytosol
ReviewStatus
5/5
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TTL ligates L-Tyr to the carboxy terminus of detyr-alpha tubulin:beta tubulin
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TTL (tubulin tyrosine ligase) ligates tyrosine (L-Tyr) to the carboxy terminus of the alpha-tubulin subunit of an alpha tubulin:beta tubulin dimer in an ATP-dependent reaction. Human TTL has not been characterized in detail; the reaction mechanism annotated here has been worked out with bovine proteins (Deans et al. 1992), and structural studies with chicken proteins demonstrate the basis of the enzyme's specificity for the carboxy terminus of tubulin alpha chains (Prota et al. 2013).
Literature References
PubMed ID Title Journal Year
23358242 Structural basis of tubulin tyrosination by tubulin tyrosine ligase

Prota, AE, Magiera, MM, Kuijpers, M, Bargsten, K, Frey, D, Wieser, M, Jaussi, R, Hoogenraad, CC, Kammerer, RA, Janke, C, Steinmetz, MO

J. Cell Biol. 2013
1520276 Steady-state kinetic mechanism of bovine brain tubulin: tyrosine ligase

Deans, NL, Allison, RD, Purich, DL

Biochem. J. 1992
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Output
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as an event of
Catalyst Activity

tubulin-tyrosine ligase activity of TTL [cytosol]

Physical Entity
TTL [cytosol] (Homo sapiens)
Activity
tubulin-tyrosine ligase activity (GO:0004835)
Inferred From
TTL ligates L-Tyr to the carboxy terminus of alpha-tubulin (Bos taurus)
Authored
D'Eustachio, P  (2017-01-13)
Reviewed
Jassal, B  (2017-01-19)
Created
D'Eustachio, P  (2017-01-13)
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