TTL ligates L-Tyr to the carboxy terminus of alpha-tubulin

Stable Identifier
R-HSA-8955706
Type
Reaction [transition]
Species
Homo sapiens
Compartment
Locations in the PathwayBrowser
General
SVG |   | PPTX  | SBGN
Click the image above or here to open this reaction in the Pathway Browser
The layout of this reaction may differ from that in the pathway view due to the constraints in pathway layout

TTL (tubulin tyrosine ligase) ligates tyrosine (L-Tyr) to the carboxy terminus of the alpha-tubulin subunit of an alpha tubulin:beta tubulin dimer in an ATP-dependent reaction. Human TTL has not been characterized in detail; the reaction mechanism annotated here has been worked out with bovine proteins (Deans et al. 1992), and structural studies with chicken proteins demonstrate the basis of the enzyme's specificity for the carboxy terminus of tubulin alpha chains (Prota et al. 2013).

Literature References
PubMed ID Title Journal Year
1520276 Steady-state kinetic mechanism of bovine brain tubulin: tyrosine ligase

Deans, NL, Allison, RD, Purich, DL

Biochem. J. 1992
23358242 Structural basis of tubulin tyrosination by tubulin tyrosine ligase

Prota, AE, Magiera, MM, Kuijpers, M, Bargsten, K, Frey, D, Wieser, M, Jaussi, R, Hoogenraad, CC, Kammerer, RA, Janke, C, Steinmetz, MO

J. Cell Biol. 2013
Participants
Participant Of
Catalyst Activity
Catalyst Activity
Title
tubulin-tyrosine ligase activity of TTL [cytosol]
Physical Entity
Activity
Inferred From
Authored
Reviewed
Created