Atp2b2-wa (PMCA2-wa) transports Ca2+ from the cytosol to the extracellular region

Stable Identifier
R-RNO-9664232
Type
Reaction [transition]
Species
Rattus norvegicus
Compartment
plasma membrane
ReviewStatus
5/5
General
SVG | 
PNG
Low
Medium
High
 | PPTX  | SBGN
Atp2b2-wa (PMCA2-wa) transports Ca2+ from the cytosol to the extracellular region
Atp2b2 (wa isoform) located in the plasma membrane of stereocilia bundles of inner hair cells and outer hair cells transports calcium ions from the cytosol to the extracellular region with concomitant hydrolysis of ATP (Dumont et al. 2001, Grati et al. 2006, Hill et al. 2006, Chen et al. 2012). Atp2b2 appears to facilitate an efflux of calcium ions that enter the stereocilia during depolarization caused by the opening of the mechanoelectrical transduction channel, hence Atp2b2 plays a role in repolarization of the cell (Beurg et al. 2010)
Literature References
PubMed ID Title Journal Year
16763025 Splice-site A choice targets plasma-membrane Ca2+-ATPase isoform 2 to hair bundles

Hill, JK, Williams, DE, LeMasurier, M, Dumont, RA, Strehler, EE, Gillespie, PG

J. Neurosci. 2006
22672315 The development, distribution and density of the plasma membrane calcium ATPase 2 calcium pump in rat cochlear hair cells

Chen, Q, Mahendrasingam, S, Tickle, JA, Hackney, CM, Furness, DN, Fettiplace, R

Eur. J. Neurosci. 2012
11438582 Plasma membrane Ca2+-ATPase isoform 2a is the PMCA of hair bundles

Dumont, RA, Lins, U, Filoteo, AG, Penniston, JT, Kachar, B, Gillespie, PG

J. Neurosci. 2001
20427623 Calcium balance and mechanotransduction in rat cochlear hair cells

Beurg, M, Nam, JH, Chen, Q, Fettiplace, R

J. Neurophysiol. 2010
16803870 Molecular determinants for differential membrane trafficking of PMCA1 and PMCA2 in mammalian hair cells

Grati, M, Aggarwal, N, Strehler, EE, Wenthold, RJ

J. Cell. Sci. 2006
Participants
Input
Output
Catalyst Activity

P-type calcium transporter activity of Atp2b2 [plasma membrane]

Physical Entity
Atp2b2 [plasma membrane] (Rattus norvegicus)
Activity
P-type calcium transporter activity (GO:0005388)
Orthologous Events
ATP2B2-wa (PMCA2-wa) transports Ca2+ from the cytosol to the extracellular region (Homo sapiens)
Authored
May, B  (2019-10-21)
Reviewed
Furness, DN  (2020-09-14)
Dallos, P  (2020-09-14)
Created
May, B  (2019-10-22)
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