Retrotranslocation of the misfolded CFTR F508del likely depends on the ERAD ATPase VCP (reviewed in Vembar and Brodsky, 2008; Pranke and Sermet-Gaudelus, 2014).
Sermet-Gaudelus, I, Pranke, IM
Vembar, SS, Brodsky, JL
Gain of function of ub-CFTR F508del:ERAD complex [endoplasmic reticulum membrane]
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