Acireductone is created

Stable Identifier
R-HSA-1237129
Type
Reaction [transition]
Species
Homo sapiens
Compartment
cytosol
Synonyms
5-methylsulfanyl-2,3-dioxopentyl phosphate + H2O => 1,2-dihydroxy-5-(methylsulfanyl)pent-1-en-3-one + phosphate
ReviewStatus
5/5
Locations in the PathwayBrowser
Expand all
General
SVG | 
PNG
Low
Medium
High
 | PPTX  | SBGN
Acireductone is created
Click the image above or here to open this reaction in the Pathway Browser
The layout of this reaction may differ from that in the pathway view due to the constraints in pathway layout
Acireductone synthase (also: enolase-phosphatase E1) catalyzes the dephosphorylation and conversion to enolate of 2,3-dioxo-5'-methylthiopentane-1-phosphate, yielding acireductone. (Wang et al, 2005)
Literature References
PubMed ID Title Journal Year
15843022 Crystal structure of human E1 enzyme and its complex with a substrate analog reveals the mechanism of its phosphatase/enolase activity

Wang, H, Pang, H, Bartlam, M, Rao, Z

J Mol Biol 2005
Participants
Input
Output
Participates
as an event of
Catalyst Activity

acireductone synthase activity of E1:Mg++ [cytosol]

Physical Entity
E1:Mg++ [cytosol] (Homo sapiens)
Activity
acireductone synthase activity (GO:0043874)
Orthologous Events
Acireductone is created (Bos taurus)
Acireductone is created (Caenorhabditis elegans)
Acireductone is created (Canis familiaris)
Acireductone is created (Danio rerio)
Acireductone is created (Dictyostelium discoideum)
Acireductone is created (Drosophila melanogaster)
Acireductone is created (Gallus gallus)
Acireductone is created (Mus musculus)
Acireductone is created (Rattus norvegicus)
Acireductone is created (Saccharomyces cerevisiae)
Acireductone is created (Schizosaccharomyces pombe)
Acireductone is created (Sus scrofa)
Acireductone is created (Xenopus tropicalis)
Cross References
RHEA
Authored
Stephan, R  (2010-10-24)
Reviewed
D'Eustachio, P  (2011-05-23)
Hill, DP  (2025-02-25)
Created
Jassal, B  (2011-03-30)
Cite Us!