Reactome | FBP tetramers hydrolyze F1,6PP to Fru(6)P

FBP tetramers hydrolyze F1,6PP to Fru(6)P

Stable Identifier

R-HSA-70479

Type

Reaction [transition]

Species

Homo sapiens

Compartment

cytosol

Synonyms

beta-D-fructose 1,6-bisphosphate + H2O => beta-D-fructose 6-phosphate + phosphate

ReviewStatus

5/5

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FBP tetramers hydrolyze F1,6PP to Fru(6)P

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Cytosolic FBP (fructose-1,6-bisphosphatase) tetramers catalyze the physiologically irreversible hydrolysis of F1,6PP (fructose-1,6-bisphosphate) to form Fru(6)P (fructose-6-phosphate) and Pi (orthophosphate). In the body, two isoforms of the enzyme are expressed, one ubiquitous and one muscle-specific (Kikawa et al. 1997; Tillmann and Eschrich 1998).

Literature References

PubMed ID	Title	Journal	Year
9382095	Identification of genetic mutations in Japanese patients with fructose-1,6-bisphosphatase deficiency Nakai, A, Taketo, A, Sudo, M, Yamamoto, Y, Jin, BY, Fujisawa, K, Hata, I, Mayumi, M, Kaji, S, Inuzuka, M, Kikawa, Y, Mizunuma, H, Shigematsu, Y, Koga, J-i	Am J Hum Genet	1997
9678974	Isolation and characterization of an allelic cDNA for human muscle fructose-1,6-bisphosphatase Tillmann, H, Eschrich, K	Gene	1998