D-fructose 1,6-bisphosphate + H2O => D-fructose 6-phosphate + orthophosphate

Stable Identifier
R-HSA-70479
Type
Reaction [transition]
Species
Homo sapiens
Compartment
Locations in the PathwayBrowser
General
SVG |   | PPTX  | SBGN
Click the image above or here to open this reaction in the Pathway Browser
The layout of this reaction may differ from that in the pathway view due to the constraints in pathway layout

Cytosolic fructose-1,6-bisphosphatase catalyzes the physiologically irreversible hydrolysis of fructose-1,6-bisphosphate to form fructose-6-phosphate and orthophosphate. In the body, two isoforms of the enzyme are expressed, one ubiquitous and one muscle-specific (Kikawa et al. 1997; Tillmann and Eschrich 1998).

Literature References
PubMed ID Title Journal Year
9678974 Isolation and characterization of an allelic cDNA for human muscle fructose-1,6-bisphosphatase

Tillmann, H, Eschrich, K

Gene 1998
9382095 Identification of genetic mutations in Japanese patients with fructose-1,6-bisphosphatase deficiency

Kikawa, Y, Inuzuka, M, Jin, BY, Kaji, S, Koga, J-i, Yamamoto, Y, Fujisawa, K, Hata, I, Nakai, A, Shigematsu, Y, Mizunuma, H, Taketo, A, Mayumi, M, Sudo, M

Am J Hum Genet 1997
Participants
Participant Of
hasEvent
Catalyst Activity
Catalyst Activity
Title
fructose 1,6-bisphosphate 1-phosphatase activity of FBP tetramer [cytosol]
Physical Entity
Activity
This event is regulated
Negatively by
Orthologous Events
Reviewed