Reactome | ABCG4 may mediate cholesterol efflux

ABCG4 may mediate cholesterol efflux

Stable Identifier

R-HSA-1454928

Type

Reaction [transition]

Species

Homo sapiens

Compartment

cytosol, extracellular region, plasma membrane

ReviewStatus

5/5

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Human ABCG4 shows sequence homology to the Drosophila white gene, the product of which must dimerise to become functionally active. ABCG4 is closely related to ABCG1 with 74% identity and is thus thought to play a role in the efflux of excess cholesterol (Engel et al. 2001). Northern Blot analysis shows that ABCG4 is expressed specifically in brain and the eye (Oldfield et al. 2002).

Literature References

PubMed ID	Title	Journal	Year
11606068	The human ABCG4 gene is regulated by oxysterols and retinoids in monocyte-derived macrophages Assmann, G, Rust, S, Schlüter, B, Lueken, A, Lorkowski, S, Cullen, P, Engel, T, Berger, G	Biochem Biophys Res Commun	2001
12183068	ABCG4: a novel human white family ABC-transporter expressed in the brain and eye Ruddick, J, Oldfield, S, Lowry, C, Lightman, S	Biochim Biophys Acta	2002