ABCG4 may mediate cholesterol efflux

Stable Identifier
Reaction [transition]
Homo sapiens
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Human ABCG4 shows sequence homology to the Drosophila white gene, the product of which must dimerise to become functionally active. ABCG4 is closely related to ABCG1 with 74% identity and is thus thought to play a role in the efflux of excess cholesterol (Engel et al. 2001). Northern Blot analysis shows that ABCG4 is expressed specifically in brain and the eye (Oldfield et al. 2002).

Literature References
PubMed ID Title Journal Year
12183068 ABCG4: a novel human white family ABC-transporter expressed in the brain and eye

Oldfield, S, Lowry, C, Ruddick, J, Lightman, S

Biochim Biophys Acta 2002
11606068 The human ABCG4 gene is regulated by oxysterols and retinoids in monocyte-derived macrophages

Engel, T, Lorkowski, S, Lueken, A, Rust, S, Schl├╝ter, B, Berger, G, Cullen, P, Assmann, G

Biochem Biophys Res Commun 2001
Catalyst Activity

cholesterol transfer activity of ABCG4 dimer [plasma membrane]

Orthologous Events
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