I3P is dephosphorylated to Ins by IMPA1/2 in the cytosol

Stable Identifier
R-HSA-1855210
Type
Reaction [transition]
Species
Homo sapiens
Compartment
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Inositol monophosphatase 1 (IMPA1) and 2 (IMPA2) homodimers dephosphorylate inositol 3-phosphate (I3P) to inositol (Ins). In vitro, IMPA1 and 2 differ in their pH optima and IMPA1 has a significantly greater activity on IP4 than does IMPA2 (Ohnishi et al. 2007).

Literature References
PubMed ID Title Journal Year
17068342 Spatial expression patterns and biochemical properties distinguish a second myo-inositol monophosphatase IMPA2 from IMPA1

Ohnishi, T, Ohba, H, Seo, KC, Im, J, Sato, Y, Iwayama, Y, Furuichi, T, Chung, SK, Yoshikawa, T

J Biol Chem 2007
Participants
Participant Of
Catalyst Activity
Catalyst Activity
Title
inositol monophosphate 3-phosphatase activity of IMPA1/2 [cytosol]
Physical Entity
Activity
Orthologous Events
Cross References
Rhea
Authored
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Created
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