Transport of Antigen peptide in to ER

Stable Identifier
R-HSA-983144
Type
Reaction [transition]
Species
Homo sapiens
Compartment
endoplasmic reticulum lumen, cytosol, endoplasmic reticulum membrane
ReviewStatus
5/5
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Transport of Antigen peptide in to ER
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Transporter associated with antigen processing (TAP) is a heterodimeric complex, composed of TAP1 and TAP2 proteins, members of the ATP-binding cassette (ABC) superfamily. TAP consists of two transmembrane domains (TMDs) and two cytosolic nucleotide-binding domains. Peptide binding to the cytosolic-facing cavity formed by the TMDs causes it to undergo a conformational change that induces ATP hydrolysis, forcing the opening of a pore and translocation of the peptide into the ER lumen. TAP transports peptides in the range of 8-16 amino acids into the ER, which is the peptide length typically generated by the immunoproteasome.
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Catalyst Activity

ABC-type peptide antigen transporter activity of TAP [endoplasmic reticulum membrane]

Physical Entity
TAP [endoplasmic reticulum membrane] (Homo sapiens)
Activity
ABC-type peptide antigen transporter activity (GO:0015433)
Orthologous Events
Transport of Antigen peptide in to ER (Bos taurus)
Transport of Antigen peptide in to ER (Caenorhabditis elegans)
Transport of Antigen peptide in to ER (Mus musculus)
Transport of Antigen peptide in to ER (Rattus norvegicus)
Transport of Antigen peptide in to ER (Schizosaccharomyces pombe)
Transport of Antigen peptide in to ER (Sus scrofa)
Authored
Garapati, P V  (2010-10-29)
Reviewed
Elliott, T  (2011-02-11)
Created
Garapati, P V  (2010-10-29)
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