Transport of Antigen peptide in to ER

Stable Identifier
R-HSA-983144
Type
Reaction [transition]
Species
Homo sapiens
Compartment
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Ttransporter associated with antigen processing (TAP) is a heterodimeric complex, composed of TAP1 and TAP2 proteins, members of the ATP-binding cassette (ABC) superfamily. TAP consists of two transmembrane domains (TMDs) and two cytosolic nucleotide-binding domains. Peptide binding to the cytosolic-facing cavity formed by the TMDs causes it to undergo a conformational change that induces ATP hydrolysis, forcing the opening of a pore and translocation of the peptide into the ER lumen. TAP transports peptides in the range of 8-16 amino acids into the ER, which is the peptide length typically generated by the immunoproteasome.

Literature References
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Catalyst Activity
Catalyst Activity
Title
ATPase-coupled peptide antigen transmembrane transporter activity of TAP [endoplasmic reticulum membrane]
Physical Entity
Activity
Orthologous Events
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Created