Reactome | Transport of Antigen peptide in to ER

Transport of Antigen peptide in to ER

Stable Identifier

R-HSA-983144

Type

Reaction [transition]

Species

Homo sapiens

Compartment

endoplasmic reticulum lumen, cytosol, endoplasmic reticulum membrane

ReviewStatus

5/5

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Ttransporter associated with antigen processing (TAP) is a heterodimeric complex, composed of TAP1 and TAP2 proteins, members of the ATP-binding cassette (ABC) superfamily. TAP consists of two transmembrane domains (TMDs) and two cytosolic nucleotide-binding domains. Peptide binding to the cytosolic-facing cavity formed by the TMDs causes it to undergo a conformational change that induces ATP hydrolysis, forcing the opening of a pore and translocation of the peptide into the ER lumen. TAP transports peptides in the range of 8-16 amino acids into the ER, which is the peptide length typically generated by the immunoproteasome.

Literature References

PubMed ID	Title	Journal	Year
8342042	Selective and ATP-dependent translocation of peptides by the MHC-encoded transporter Hämmerling, GJ, Momburg, F, Neefjes, JJ	Science	1993
10600378	Kinetic analysis of peptide binding to the TAP transport complex: evidence for structural rearrangements induced by substrate binding Tampé, R, Neumann, L	J Mol Biol	1999
19261456	Antigen processing and presentation: TAPping into ABC transporters Procko, E, Gaudet, R	Curr Opin Immunol	2009
12645939	The ABC-transporter signature motif is required for peptide translocation but not peptide binding by TAP Hewitt, EW, Lehner, PJ	Eur J Immunol	2003