RHOD GAPs stimulate RHOD GTPase activity

Stable Identifier
R-HSA-9013437
Type
Reaction [transition]
Species
Homo sapiens
Compartment
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The following GTPase activating proteins (GAPs) were shown to bind RHOD and stimulate its GTPase activity, resulting in GTP to GDP hydrolysis and conversion of the active RHOD:GTP complex to the inactive RHOD:GDP complex (the study by Bagci et al. 2020 is cited as supporting evidence since it only examined binding of GAPs to active RHOD without testing for RHOD-directed GAP activity):
ARHGAP1 (Amin et al. 2016; supported by Bagci et al. 2020)
ARHGAP26 (Amin et al. 2016)
ARHGAP32 (Paul et al. 2017; supported by Bagci et al. 2020)
ARHGAP35 (Amin et al. 2016; supported by Bagci et al. 2020)

The following GAPs were shown to bind RHOD and stimulate its GTPase activity in some but not all studies or were shown by Bagci et al. 2020 to bind to active RHOD without testing for RHOD-directed GAP activity and are annotated as candidate RHOD GAPs:
ARHGAP5 (Bagci et al. 2020)
ARHGAP12 (Bagci et al. 2020)
ARHGAP17 (Amin et al. 2016: RHOD directed GAP activity; Bagci et al. 2020: no binding to active RHOD)
ARHGAP21 (Bagci et al. 2020)
ARHGAP39 (Bagci et al. 2020)
DEPDC1B (Bagci et al. 2020)
PIK3R1 (Bagci et al. 2020)
PIK3R2 (Bagci et al. 2020)
RACGAP1 (Amin et al. 2016: RHOD directed GAP activity; Bagci et al. 2020: no binding to active RHOD)

The following GAPs do not act on RHOD or were shown by Bagci et al. 2020 to not bind to active RHOD:
ABR (Amin et al. 2016; Bagci et al. 2020)
ARAP2 (Bagci et al. 2020)
ARAP3 (Bagci et al. 2020)
ARHGAP29 (Bagci et al. 2020)
ARHGAP31 (Bagci et al. 2020)
ARHGAP42 (Bagci et al. 2020)
BCR (Bagci et al. 2020)
DLC1 (Amin et al. 2016)
MYO9A (Bagci et al. 2020)
MYO9B (Bagci et al. 2020)
OPHN1 (Amin et al. 2016; Bagci et al. 2020)
SRGAP2 (Bagci et al. 2020)
STARD13 (Amin et al. 2016)
STARD8 (Amin et al. 2016)
SYDE1 (Bagci et al. 2020)

Literature References
PubMed ID Title Journal Year
27852748 Quantitative GTPase Affinity Purification Identifies Rho Family Protein Interaction Partners

Paul, F, Zauber, H, von Berg, L, Rocks, O, Daumke, O, Selbach, M

Mol. Cell Proteomics 2017
27481945 Deciphering the Molecular and Functional Basis of RHOGAP Family Proteins: A SYSTEMATIC APPROACH TOWARD SELECTIVE INACTIVATION OF RHO FAMILY PROTEINS

Amin, E, Jaiswal, M, Derewenda, U, Reis, K, Nouri, K, Koessmeier, KT, Aspenström, P, Somlyo, AV, Dvorsky, R, Ahmadian, MR

J. Biol. Chem. 2016
31871319 Mapping the proximity interaction network of the Rho-family GTPases reveals signalling pathways and regulatory mechanisms

Bagci, H, Sriskandarajah, N, Robert, A, Boulais, J, Elkholi, IE, Tran, V, Lin, ZY, Thibault, MP, Dubé, N, Faubert, D, Hipfner, DR, Gingras, AC, Cote, JF

Nat. Cell Biol. 2020
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GTPase activator activity of RHOD GAPs [cytosol]

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