Reactome | 5-phosphoribosylamine + glycine + ATP <=> 5-phosphoribosylglycinamide (GAR) + adenosine 5'-diphosphate + orthophosphate

5-phosphoribosylamine + glycine + ATP <=> 5-phosphoribosylglycinamide (GAR) + adenosine 5'-diphosphate + orthophosphate

Stable Identifier

R-GGA-419153

Type

Reaction [transition]

Species

Gallus gallus

Compartment

cytosol

ReviewStatus

5/5

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5-phosphoribosylamine + glycine + ATP <=> 5-phosphoribosylglycinamide (GAR) + adenosine 5'-diphosphate + orthophosphate

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The phosphoribosylamine-glycine ligase activity of cytosolic GART (trifunctional purine biosynthetic protein adenosine-3) catalyzes the reaction of 5-phosphoribosylamine, glycine, and ATP to form 5-phosphoribosylglycinamide (GAR), adenosine 5'-diphosphate, and orthophosphate. GART trifunctional protein has been purified from chicken liver (Daubner et al. 1985), and a cDNA encoding the chicken enzyme has been identified based on sequence similarities and its ability to complement E. coli cells whose homologous purine biosynthesis genes were mutated (Aimi et al. 1990). The subcellular location of the chicken enzyme is inferred from that of its better-characterized mammalian counterparts.

Literature References

PubMed ID	Title	Journal	Year
2147474	De novo purine nucleotide biosynthesis: cloning of human and avian cDNAs encoding the trifunctional glycinamide ribonucleotide synthetase-aminoimidazole ribonucleotide synthetase-glycinamide ribonucleotide transformylase by functional complementation in E. coli Aimi, J, Qiu, H, Williams, J, Zalkin, H, Dixon, JE	Nucleic Acids Res	1990
4084560	A multifunctional protein possessing glycinamide ribonucleotide synthetase, glycinamide ribonucleotide transformylase, and aminoimidazole ribonucleotide synthetase activities in de novo purine biosynthesis Daubner, SC, Schrimsher, JL, Schendel, FJ, Young, M, Henikoff, S, Patterson, D, Stubbe, J, Benkovic, SJ	Biochemistry	1985

Participants

Input

Output

Participates

as an event of

De novo synthesis of IMP (Gallus gallus)

Catalyst Activity

phosphoribosylamine-glycine ligase activity of GART [cytosol]

Physical Entity

GART [cytosol] (Gallus gallus)

Activity

phosphoribosylamine-glycine ligase activity (GO:0004637)

Authored

D'Eustachio, P (2009-04-29)

Created

D'Eustachio, P (2009-04-29)

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