NdkA dephosphorylates RAB5A:GTP,RAB7A:GTP

Stable Identifier
R-HSA-9636684
Type
Reaction [transition]
Species
Homo sapiens
Related Species
Mycobacterium tuberculosis
Compartment
cytosol
ReviewStatus
5/5
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NdkA dephosphorylates RAB5A:GTP,RAB7A:GTP
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Ras-related protein with guanosine 5'-triphosphates bound to GTP (RAB5A:GTP,RAB7A:GTP) get deactivated through dephosphorylation of GTP via the GTPase-activating protein (GAP)-like activity of the Mtb nucleoside diphosphate kinase (ndkA) (Chopra et al. 2004, Sun et al. 2010).
Literature References
PubMed ID Title Journal Year
20098737 Mycobacterial nucleoside diphosphate kinase blocks phagosome maturation in murine RAW 264.7 macrophages

Hmama, Z, Liao, TY, Sun, J, Bucci, C, Lau, A, Wang, X

PLoS ONE 2010
15280044 Nucleoside diphosphate kinase of Mycobacterium tuberculosis acts as GTPase-activating protein for Rho-GTPases

Sharma, K, Ghildiyal, M, Chopra, P, Koduri, H, Singh, R, Tyagi, AK, Koul, A, Singh, Y

FEBS Lett. 2004
Participants
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Output
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as an event of
Catalyst Activity

phosphoprotein phosphatase activity of NdkA [cytosol]

Physical Entity
NdkA [cytosol] (Mycobacterium tuberculosis)
Activity
phosphoprotein phosphatase activity (GO:0004721)
Disease
Name Identifier Synonyms
tuberculosis DOID:399 tuberculous abscess, Tuberculoma (finding), tuberculoma
Authored
Stephan, R  (2019-02-06)
Reviewed
Wilkinson, RJ  (2019-10-23)
Deffur, A  (2019-10-23)
Created
Koile, I  (2019-02-13)
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