ndkA dephosphorylates RAB5A:GTP,RAB7A:GTP

Stable Identifier
R-HSA-9636684
Type
Reaction [transition]
Species
Homo sapiens
Related Species
Mycobacterium tuberculosis
Compartment
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Ras-related protein with guanosine 5'-triphosphates bound to GTP (RAB5A:GTP,RAB7A:GTP) get deactivated through dephosphorylation of GTP via the GTPase-activating protein (GAP)-like activity of the Mtb nucleoside diphosphate kinase (ndkA) (Chopra et al. 2004, Sun et al. 2010).

Literature References
PubMed ID Title Journal Year
15280044 Nucleoside diphosphate kinase of Mycobacterium tuberculosis acts as GTPase-activating protein for Rho-GTPases

Chopra, P, Koduri, H, Singh, R, Koul, A, Ghildiyal, M, Sharma, K, Tyagi, AK, Singh, Y

FEBS Lett. 2004
20098737 Mycobacterial nucleoside diphosphate kinase blocks phagosome maturation in murine RAW 264.7 macrophages

Sun, J, Wang, X, Lau, A, Liao, TY, Bucci, C, Hmama, Z

PLoS ONE 2010
Participants
Participant Of
Catalyst Activity
Catalyst Activity
Title
phosphoprotein phosphatase activity of ndkA [cytosol]
Physical Entity
Activity
Disease
Name Identifier Synonyms
tuberculosis 399 tuberculous abscess, Tuberculoma (finding), tuberculoma
Authored
Reviewed
Created
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