De-phosphorylation of p-Y427-SHC1

Stable Identifier
Reaction [omitted]
Homo sapiens
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At the beginning of this reaction, 1 molecule of 'phospho-SHC' is present. At the end of this reaction, 1 molecule of 'Orthophosphate', and 1 molecule of 'SHC transforming protein' are present.

This reaction takes place in the 'cytosol' and is mediated by the 'protein tyrosine phosphatase activity' of 'protein tyrosine phosphatase' (Sasaoka et al. 1996).
This is a black box event since the event of dephosphorylation is inferred from other reaction where this process occurs after other stimulation (Gu et al. 1999).

Literature References
PubMed ID Title Journal Year
21884975 Rapid phospho-turnover by receptor tyrosine kinases impacts downstream signaling and drug binding

Sorger, PK, Kleiman, LB, Maiwald, T, Conzelmann, H, Lauffenburger, DA

Mol. Cell 2011
8702728 Functional importance of amino-terminal domain of Shc for interaction with insulin and epidermal growth factor receptors in phosphorylation-independent manner

Imamura, T, Sawa, T, Sasaoka, T, Usui, I, Takata, Y, Ishihara, H, Kobayashi, M, Morioka, H, Ishiki, M

J. Biol. Chem. 1996
10427092 Shc and FAK differentially regulate cell motility and directionality modulated by PTEN

Gu, J, Takino, T, Pankov, R, Tamura, M, Matsumoto, K, Yamada, KM, Danen, EH

J. Cell Biol. 1999
Catalyst Activity

protein tyrosine phosphatase activity of protein tyrosine phosphatase [cytosol]

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