Reactome | PI(3,5)P2 is dephosphorylated to PI5P by MTMR9-bound MTMR6 or MTMR8 at the plasma membrane

PI(3,5)P2 is dephosphorylated to PI5P by MTMR9-bound MTMR6 or MTMR8 at the plasma membrane

Stable Identifier

R-HSA-6809320

Type

Reaction [transition]

Species

Homo sapiens

Compartment

plasma membrane, cytosol

ReviewStatus

5/5

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PI(3,5)P2 is dephosphorylated to PI5P by MTMR9-bound MTMR6 or MTMR8 at the plasma membrane

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Formation of a complex with MTMR9 results in a 30-fold increase of phosphatidylinositol-(3,5)-bisphosphate 3-phosphatase catalytic activity of MTMR6 and a modest increase in the catalytic activity of MTMR8 (Zou et al. 2009, Zou et al. 2012).

Literature References

PubMed ID	Title	Journal	Year
19038970	MTMR9 increases MTMR6 enzyme activity, stability, and role in apoptosis Zou, J, Chang, SC, Marjanovic, J, Majerus, PW	J. Biol. Chem.	2009
22647598	Myotubularin-related protein (MTMR) 9 determines the enzymatic activity, substrate specificity, and role in autophagy of MTMR8 Zou, J, Zhang, C, Marjanovic, J, Kisseleva, MV, Majerus, PW, Wilson, MP	Proc. Natl. Acad. Sci. U.S.A.	2012