PI(3,5)P2 is dephosphorylated to PI5P by MTMR9-bound MTMR6 or MTMR8 at the plasma membrane

Stable Identifier
R-HSA-6809320
Type
Reaction [transition]
Species
Homo sapiens
Compartment
ReviewStatus
5/5
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Formation of a complex with MTMR9 results in a 30-fold increase of phosphatidylinositol-(3,5)-bisphosphate 3-phosphatase catalytic activity of MTMR6 and a modest increase in the catalytic activity of MTMR8 (Zou et al. 2009, Zou et al. 2012).
Literature References
PubMed ID Title Journal Year
19038970 MTMR9 increases MTMR6 enzyme activity, stability, and role in apoptosis

Marjanovic, J, Majerus, PW, Chang, SC, Zou, J

J. Biol. Chem. 2009
22647598 Myotubularin-related protein (MTMR) 9 determines the enzymatic activity, substrate specificity, and role in autophagy of MTMR8

Marjanovic, J, Majerus, PW, Kisseleva, MV, Wilson, MP, Zhang, C, Zou, J

Proc. Natl. Acad. Sci. U.S.A. 2012
Participants
Participates
Catalyst Activity

phosphatidylinositol-3,5-bisphosphate 3-phosphatase activity of MTMR6:MTMR9,MTMR8:MTMR9 [cytosol]

Orthologous Events
Cross References
Rhea
Authored
Reviewed
Created
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