ABCAs mediate lipid influx

Stable Identifier
Reaction [transition]
Homo sapiens
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The exact roles of ABCA2 (Vulevic et al. 2001, Kaminski et al. 2001), ABCA6 (Kaminski & Wenzel et al. 2001), ABCA9 (Piehler et al. 2002) and ABCA10 (Wenzel et al. 2003), candidates for ABC lipid transporter-related activities, need to be elucidated. Even thought cholesterol-responsiveness has been noted in experimental systems, contribution of these proteins in regulation or in active transport is not yet clear.

Literature References
PubMed ID Title Journal Year
12150964 Molecular structure of a novel cholesterol-responsive A subclass ABC transporter, ABCA9

Piehler, A, Kaminski, WE, Wenzel, JJ, Langmann, T, Schmitz, G

Biochem Biophys Res Commun 2002
11178988 Complete coding sequence, promoter region, and genomic structure of the human ABCA2 gene and evidence for sterol-dependent regulation in macrophages

Kaminski, WE, Piehler, A, Püllmann, K, Porsch-Ozcürümez, M, Duong, C, Bared, GM, Büchler, C, Schmitz, G

Biochem Biophys Res Commun 2001
11478798 ABCA6, a novel a subclass ABC transporter

Kaminski, WE, Wenzel, JJ, Piehler, A, Langmann, T, Schmitz, G

Biochem Biophys Res Commun 2001
12821155 ABCA10, a novel cholesterol-regulated ABCA6-like ABC transporter

Wenzel, JJ, Kaminski, WE, Piehler, A, Heimerl, S, Langmann, T, Schmitz, G

Biochem Biophys Res Commun 2003
11309290 Cloning and characterization of human adenosine 5'-triphosphate-binding cassette, sub-family A, transporter 2 (ABCA2)

Vulevic, B, Chen, Z, Boyd, JT, Davis W, Jr, Walsh, ES, Belinsky, MG, Tew, KD

Cancer Res 2001
Event Information
Catalyst Activity

lipid transporter activity of ABCA cholesterol transporters [plasma membrane]

Orthologous Events
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