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Dephosphorylation of p-Y-IRS1,p-Y-IRS2
Stable Identifier
R-HSA-74747
Type
Reaction [transition]
Species
Homo sapiens
Compartment
cytosol
ReviewStatus
5/5
Locations in the PathwayBrowser
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Signal Transduction (Homo sapiens)
Signaling by Receptor Tyrosine Kinases (Homo sapiens)
Signaling by Insulin receptor (Homo sapiens)
Insulin receptor signalling cascade (Homo sapiens)
Signal attenuation (Homo sapiens)
Dephosphorylation of p-Y-IRS1,p-Y-IRS2 (Homo sapiens)
General
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The layout of this reaction may differ from that in the pathway view due to the constraints in pathway layout
At the beginning of this reaction, 1 molecule of 'phospho-IRS' is present. At the end of this reaction, 1 molecule of 'Orthophosphate', and 1 molecule of 'IRS' are present.
This reaction takes place in the 'cytosol' and is mediated by the 'protein tyrosine phosphatase activity' of 'protein tyrosine phosphatase' (Pederson et al.2001).
Participants
Input
p-Y-IRS1,p-Y-IRS2 [cytosol]
(Homo sapiens)
Output
IRS1,2 [cytosol]
(Homo sapiens)
Pi [cytosol]
Participates
as an event of
Signal attenuation (Homo sapiens)
Catalyst Activity
protein tyrosine phosphatase activity of protein tyrosine phosphatase [cytosol]
Physical Entity
protein tyrosine phosphatase [cytosol]
(Homo sapiens)
Activity
protein tyrosine phosphatase activity (GO:0004725)
Created
Bevan, AP (2003-07-31)
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