Inactivation of Cdc42

Stable Identifier
R-NUL-428519
Type
Reaction [transition]
Species
Rattus norvegicus
Compartment
cytosol, plasma membrane
ReviewStatus
5/5
General
SVG | 
PNG
Low
Medium
High
 | PPTX  | SBGN
Inactivation of Cdc42
Human SRGAP, bound to the cytoplasmic tail of rat Robo1, increases the intrinsic GTPase activity of human CDC42, converting the GTP-bound form of CDC42 into its GDP-bound form, therefore inactivating CDC42 (Wong et al. 2001, Li et al. 2006).
Literature References
PubMed ID Title Journal Year
16857672 Structural basis of Robo proline-rich motif recognition by the srGAP1 Src homology 3 domain in the Slit-Robo signaling pathway

Li, X, Chen, Y, Liu, Y, Gao, J, Gao, F, Bartlam, M, Wu, JY, Rao, Z

J Biol Chem 2006
11672528 Signal transduction in neuronal migration: roles of GTPase activating proteins and the small GTPase Cdc42 in the Slit-Robo pathway

Wong, K, Ren, XR, Huang, YZ, Xie, Y, Liu, G, Saito, H, Tang, H, Wen, L, Brady-Kalnay, SM, Mei, L, Wu, JY, Xiong, WC, Rao, Y

Cell 2001
Participants
Input
Output
Catalyst Activity

GTPase activator activity of Robo1:Slit2:SrGAP [plasma membrane]

Physical Entity
Robo1:Slit2:SrGAP [plasma membrane] (Homo sapiens)
Activity
GTPase activator activity (GO:0005096)
Orthologous Events
Inactivation of CDC42 (Homo sapiens)
Authored
Garapati, P V  (2008-09-05)
Reviewed
Kidd, T  (2009-08-18)
Jaworski, A  (2017-07-31)
Created
Garapati, P V  (2009-07-06)
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