Inactivation of Cdc42

Stable Identifier
R-NUL-428519
Type
Reaction [transition]
Species
Rattus norvegicus
Compartment
General
SVG |   | PPTX  | SBGN
Inactivation of Cdc42

Human SRGAP, bound to the cytoplasmic tail of rat Robo1, increases the intrinsic GTPase activity of human CDC42, converting the GTP-bound form of CDC42 into its GDP-bound form, therefore inactivating CDC42 (Wong et al. 2001, Li et al. 2006).

Literature References
PubMed ID Title Journal Year
11672528 Signal transduction in neuronal migration: roles of GTPase activating proteins and the small GTPase Cdc42 in the Slit-Robo pathway

Wong, K, Ren, XR, Huang, YZ, Xie, Y, Liu, G, Saito, H, Tang, H, Wen, L, Brady-Kalnay, SM, Mei, L, Wu, JY, Xiong, WC, Rao, Y

Cell 2001
16857672 Structural basis of Robo proline-rich motif recognition by the srGAP1 Src homology 3 domain in the Slit-Robo signaling pathway

Li, X, Chen, Y, Liu, Y, Gao, J, Gao, F, Bartlam, M, Wu, JY, Rao, Z

J Biol Chem 2006
Participants
Catalyst Activity
Catalyst Activity
Title
GTPase activator activity of Robo1:Slit2:SrGAP [plasma membrane]
Physical Entity
Activity
Orthologous Events
Authored
Reviewed
Created