ATP2B2-wa (PMCA2-wa) transports Ca2+ from the cytosol to the extracellular region

Stable Identifier
R-HSA-9662114
Type
Reaction [transition]
Species
Homo sapiens
Compartment
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ATP2B2 (wa isoform) is located in the plasma membrane of stereocilia bundles of inner hair cells and outer hair cells and transports calcium ions from the cytosol to the extracellular region with concomitant hydrolysis of ATP (Ficarella et al. 2007, Giacomello et al. 2011, and observed in rat and mouse). ATP2B2 appears to facilitate an efflux of calcium ions that enter the stereocilia during depolarization caused by the opening of the mechanoelectrical transduction channel, hence ATP2B2 plays a role in repolarization of the cell (Ficarella et al. 2007, Giacomello et al. 2011, and observed in rat and mouse).

Literature References
PubMed ID Title Journal Year
22047666 Mutations in PMCA2 and hereditary deafness: a molecular analysis of the pump defect

Giacomello, M, De Mario, A, Lopreiato, R, Primerano, S, Campeol, M, Brini, M, Carafoli, E

Cell Calcium 2011
17234811 A functional study of plasma-membrane calcium-pump isoform 2 mutants causing digenic deafness

Ficarella, R, Di Leva, F, Bortolozzi, M, Ortolano, S, Donaudy, F, Petrillo, M, Melchionda, S, Lelli, A, Domi, T, Fedrizzi, L, Lim, D, Shull, GE, Gasparini, P, Brini, M, Mammano, F, Carafoli, E

Proc. Natl. Acad. Sci. U.S.A. 2007
Participants
Participates
Catalyst Activity

calcium transmembrane transporter activity, phosphorylative mechanism of ATP2B2 isoform wa [plasma membrane]

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