Reactome | FGAR + L-Glutamine + ATP + H2O => FGAM + L-Glutamate + ADP + Pi

FGAR + L-Glutamine + ATP + H2O => FGAM + L-Glutamate + ADP + Pi

Stable Identifier

R-HSA-73812

Type

Reaction [transition]

Species

Homo sapiens

Compartment

cytosol

Synonyms

5'-phosphoribosylformylglycinamide (FGAR) + L-glutamine + ATP + H2O => 5'-phosphoribosylformylglycinamidine (FGAM) + L-glutamate + adenosine 5'-diphosphate + orthophosphate

ReviewStatus

5/5

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FGAR + L-Glutamine + ATP + H2O => FGAM + L-Glutamate + ADP + Pi

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The irreversible transfer of an amino group from L-glutamine to 5'-phosphoribosylformylglycinamide (FGAR), forming 5'-phosphoribosylformylglycinamidine (FGAM) and glutamate, accompanied by the conversion of ATP to ADP and orthophosphate, is catalyzed by phosphoribosylformylglycinamidine synthetase. The human enzyme has been purified and characterized biochemically (Barnes et al. 1994). Fluoresence microscopy studies of cultured human cells have shown that the enzyme is cytosolic and suggest that it may co-localize with other enzymes of de novo IMP biosynthesis under some metabolic conditions (An et al. 2008).

Literature References

PubMed ID	Title	Journal	Year
18388293	Reversible compartmentalization of de novo purine biosynthetic complexes in living cells An, S, Kumar, R, Sheets, ED, Benkovic, SJ	Science	2008
8110788	Purification of, generation of monoclonal antibodies to, and mapping of phosphoribosyl N-formylglycinamide amidotransferase Barnes, TS, Bleskan, JH, Hart, IM, Walton, KA, Barton, JW, Patterson, D	Biochemistry	1994