ATP2C1/2:Mg2+ transport cytosolic Ca2+ to Golgi lumen

Stable Identifier
R-HSA-936883
Type
Reaction [transition]
Species
Homo sapiens
Compartment
Synonyms
Calcium is sequestered to the golgi by secretory pathway calcium-ATPases (SPCAs)
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Accumulation of calcium into the Golgi apparatus is mediated by sarco(endo)plasmic reticulum calcium-ATPases (SERCAs) and by secretory pathway calcium-ATPases (SPCAs). There are two human genes which encode SPCAs; ATP2C1 and ATP2C2 which encode magnesium-dependent calcium-transporting ATPase type 2C members 1 and 2 (ATP2C1 and 2) respectively (Sudbrak et al, 2000; Vanoevelen et al, 2005). Defects in ATP2C1 are the cause of Hailey-Hailey disease (HHD), an autosomal dominant disease characterized by persistent blisters and erosions of the skin (Hu et al, 2000).

Literature References
PubMed ID Title Journal Year
10767338 Hailey-Hailey disease is caused by mutations in ATP2C1 encoding a novel Ca(2+) pump

Sudbrak, R, Brown, J, Dobson-Stone, C, Carter, S, Ramser, J, White, J, Healy, E, Dissanayake, M, Larrègue, M, Perrussel, M, Lehrach, H, Munro, CS, Strachan, T, Burge, S, Hovnanian, A, Monaco, AP

Hum Mol Genet 2000
10615129 Mutations in ATP2C1, encoding a calcium pump, cause Hailey-Hailey disease

Hu, Z, Bonifas, JM, Beech, J, Bench, G, Shigihara, T, Ogawa, H, Ikeda, S, Mauro, T, Epstein EH, Jr

Nat Genet 2000
15831496 The secretory pathway Ca2+/Mn2+-ATPase 2 is a Golgi-localized pump with high affinity for Ca2+ ions

Vanoevelen, J, Dode, L, Van Baelen, K, Fairclough, RJ, Missiaen, L, Raeymaekers, L, Wuytack, F

J Biol Chem 2005
Participants
Participates
Catalyst Activity

P-type calcium transporter activity of ATP2C1/2:Mg2+ [Golgi membrane]

Orthologous Events
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