ATP2C1/2:Mg2+ transport cytosolic Ca2+ to Golgi lumen

Stable Identifier
Reaction [transition]
Homo sapiens
Calcium is sequestered to the golgi by secretory pathway calcium-ATPases (SPCAs)
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Accumulation of calcium into the Golgi apparatus is mediated by sarco(endo)plasmic reticulum calcium-ATPases (SERCAs) and by secretory pathway calcium-ATPases (SPCAs). There are two human genes which encode SPCAs; ATP2C1 and ATP2C2 which encode magnesium-dependent calcium-transporting ATPase type 2C members 1 and 2 (ATP2C1 and 2) respectively (Sudbrak et al, 2000; Vanoevelen et al, 2005). Defects in ATP2C1 are the cause of Hailey-Hailey disease (HHD), an autosomal dominant disease characterized by persistent blisters and erosions of the skin (Hu et al, 2000).

Literature References
PubMed ID Title Journal Year
10615129 Mutations in ATP2C1, encoding a calcium pump, cause Hailey-Hailey disease

Ikeda, S, Shigihara, T, Epstein EH, Jr, Ogawa, H, Bonifas, JM, Hu, Z, Mauro, T, Bench, G, Beech, J

Nat Genet 2000
10767338 Hailey-Hailey disease is caused by mutations in ATP2C1 encoding a novel Ca(2+) pump

Strachan, T, Monaco, AP, Lehrach, H, Munro, CS, Healy, E, Hovnanian, A, Sudbrak, R, Larrègue, M, Dobson-Stone, C, Carter, S, White, J, Dissanayake, M, Burge, S, Perrussel, M, Ramser, J, Brown, J

Hum Mol Genet 2000
15831496 The secretory pathway Ca2+/Mn2+-ATPase 2 is a Golgi-localized pump with high affinity for Ca2+ ions

Raeymaekers, L, Missiaen, L, Fairclough, RJ, Wuytack, F, Dode, L, Van Baelen, K, Vanoevelen, J

J Biol Chem 2005
Catalyst Activity

P-type calcium transporter activity of ATP2C1/2:Mg2+ [Golgi membrane]

Orthologous Events
Cross References
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