Reactome | ATP2C1/2:Mg2+ transport cytosolic Ca2+ to Golgi lumen

ATP2C1/2:Mg2+ transport cytosolic Ca2+ to Golgi lumen

Stable Identifier

R-HSA-936883

Type

Reaction [transition]

Species

Homo sapiens

Compartment

Golgi membrane

Synonyms

Calcium is sequestered to the golgi by secretory pathway calcium-ATPases (SPCAs)

ReviewStatus

5/5

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ATP2C1/2:Mg2+ transport cytosolic Ca2+ to Golgi lumen

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Accumulation of calcium into the Golgi apparatus is mediated by sarco(endo)plasmic reticulum calcium-ATPases (SERCAs) and by secretory pathway calcium-ATPases (SPCAs). There are two human genes which encode SPCAs; ATP2C1 and ATP2C2 which encode magnesium-dependent calcium-transporting ATPase type 2C members 1 and 2 (ATP2C1 and 2) respectively (Sudbrak et al, 2000; Vanoevelen et al, 2005). Defects in ATP2C1 are the cause of Hailey-Hailey disease (HHD), an autosomal dominant disease characterized by persistent blisters and erosions of the skin (Hu et al, 2000).

Literature References

PubMed ID	Title	Journal	Year
10615129	Mutations in ATP2C1, encoding a calcium pump, cause Hailey-Hailey disease Hu, Z, Bonifas, JM, Beech, J, Bench, G, Shigihara, T, Ogawa, H, Ikeda, S, Mauro, T, Epstein EH, Jr	Nat Genet	2000
10767338	Hailey-Hailey disease is caused by mutations in ATP2C1 encoding a novel Ca(2+) pump Sudbrak, R, Brown, J, Dobson-Stone, C, Carter, S, Ramser, J, White, J, Healy, E, Dissanayake, M, Larrègue, M, Perrussel, M, Lehrach, H, Munro, CS, Strachan, T, Burge, S, Hovnanian, A, Monaco, AP	Hum Mol Genet	2000
15831496	The secretory pathway Ca2+/Mn2+-ATPase 2 is a Golgi-localized pump with high affinity for Ca2+ ions Vanoevelen, J, Dode, L, Van Baelen, K, Fairclough, RJ, Missiaen, L, Raeymaekers, L, Wuytack, F	J Biol Chem	2005