Conversion of PA into DAG by PAP-1

Stable Identifier
R-HSA-2029468
Type
Reaction
Species
Homo sapiens
Compartment
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Phosphatidic acid phosphatase (PAP) bound to the plasma membrane catalyzes the dephosphorylation of phosphatidic acid (PA), yielding diacylglycerol (DAG) and inorganic phosphate. In humans, Diacylglycerol pyrophosphate (DPPL1 and DPPL2) perform this reaction.

Literature References
PubMed ID Title Journal Year
10224668 Phospholipases and phagocytosis: the role of phospholipid-derived second messengers in phagocytosis

Lennartz, MR

Int J Biochem Cell Biol 1999
17590538 Cloning and characterization of DPPL1 and DPPL2, representatives of a novel type of mammalian phosphatidate phosphatase

Abe, J, Ball, E, Furuichi, K, Momohara, S, Takeuchi, M, Harigai, M, Kamatani, N

Gene 2007
Participants
Participates
Catalyst Activity

phosphatidate phosphatase activity of Phosphatidate phosphatase [plasma membrane]

Orthologous Events
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