Reactome | Conversion of PA into DAG by PAP-1

Conversion of PA into DAG by PAP-1

Stable Identifier

R-HSA-2029468

Type

Reaction [transition]

Species

Homo sapiens

Compartment

plasma membrane, cytosol

ReviewStatus

5/5

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Phosphatidic acid phosphatase (PAP) bound to the plasma membrane catalyzes the dephosphorylation of phosphatidic acid (PA), yielding diacylglycerol (DAG) and inorganic phosphate. In humans, Diacylglycerol pyrophosphate (DPPL1 and DPPL2) perform this reaction.

Literature References

PubMed ID	Title	Journal	Year
10224668	Phospholipases and phagocytosis: the role of phospholipid-derived second messengers in phagocytosis Lennartz, MR	Int J Biochem Cell Biol	1999
17590538	Cloning and characterization of DPPL1 and DPPL2, representatives of a novel type of mammalian phosphatidate phosphatase Takeuchi, M, Harigai, M, Momohara, S, Ball, E, Abe, J, Furuichi, K, Kamatani, N	Gene	2007