RHOJ GAPs stimulate RHOJ GTPase activity

Stable Identifier
R-HSA-9017488
Type
Reaction [transition]
Species
Homo sapiens
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The following GTPase activating proteins (GAPs) were shown to bind RHOJ and stimulate its GTPase activity, resulting in GTP to GDP hydrolysis and conversion of the active RHOJ:GTP complex into the inactive RHOJ:GDP complex (the high throughput study by Bagci et al. 2020 examined binding of GAPs to constitutively active RHOJ mutant without testing for RHOJ-directed GAP activity, and is cited as supporting evidence):
ARHGAP1 (Amin et al. 2016; supported by Bagci et al. 2020)
ARHGAP26 (Amin et al. 2016)
ARHGAP35 (Amin et al. 2016; supported by Bagci et al. 2020)

The following GAPs were shown to bind RHOJ and stimulate its GTPase activity in some but not all studies or were shown by Bagci et al. 2020 to bind to constitutively active RHOJ mutant without testing for RHOJ-directed GAP activity and are annotated as candidate RHOJ GAPs:
ARHGAP5 (Bagci et al. 2020)
ARHGAP21 (Bagci et al. 2020)
ARHGAP32 (Bagci et al. 2020)
DEPDC1B (Bagci et al. 2020)
OCRL (Bagci et al. 2020: binding to active RHOJ; Erdmann et al. 2007, Lichter Konecki et al. 2006: no RHOJ directed GAP activity:)
OPHN1 (Amin et al. 2016: RHOJ directed GAP activity; Bagci et al. 2020: no binding to active RHOJ)
PIK3R1 (Bagci et al. 2020)
PIK3R2 (Bagci et al. 2020)
SYDE1 (Bagci et al. 2020)

The following GAPs do not act on RHOJ or were shown by Bagci et al. 2020 to no bind to constitutively active RHOJ mutant and are thus unlikely to be RHOJ GAPs:
ABR (Amin et al. 2016; Bagci et al. 2020)
ARAP2 (Bagci et al. 2020)
ARAP3 (Bagci et al. 2020)
ARHGAP12 (Bagci et al. 2020)
ARHGAP17 (Amin et al. 2016; Bagci et al. 2020)
ARHGAP29 (Bagci et al. 2020)
ARHGAP31 (Bagci et al. 2020)
ARHGAP39 (Bagci et al. 2020)
ARHGAP42 (Bagci et al. 2020)
BCR (Bagci et al. 2020)
DLC1 (Amin et al. 2016)
MYO9A (Bagci et al. 2020)
MYO9B (Bagci et al. 2020)
RACGAP1 (Amin et al. 2016; Bagci et al. 2020)
SRGAP2 (Bagci et al. 2020)
STARD13 (Amin et al. 2016)
STARD8 (Amin et al. 2016)

Literature References
PubMed ID Title Journal Year
17765681 A role of the Lowe syndrome protein OCRL in early steps of the endocytic pathway

Erdmann, KS, Mao, Y, McCrea, HJ, Zoncu, R, Lee, S, Paradise, S, Modregger, J, Biemesderfer, D, Toomre, D, De Camilli, P

Dev. Cell 2007
27481945 Deciphering the Molecular and Functional Basis of RHOGAP Family Proteins: A SYSTEMATIC APPROACH TOWARD SELECTIVE INACTIVATION OF RHO FAMILY PROTEINS

Amin, E, Jaiswal, M, Derewenda, U, Reis, K, Nouri, K, Koessmeier, KT, Aspenström, P, Somlyo, AV, Dvorsky, R, Ahmadian, MR

J. Biol. Chem. 2016
16777452 The effect of missense mutations in the RhoGAP-homology domain on ocrl1 function

Lichter-Konecki, U, Farber, LW, Cronin, JS, Suchy, SF, Nussbaum, RL

Mol. Genet. Metab. 2006
31871319 Mapping the proximity interaction network of the Rho-family GTPases reveals signalling pathways and regulatory mechanisms

Bagci, H, Sriskandarajah, N, Robert, A, Boulais, J, Elkholi, IE, Tran, V, Lin, ZY, Thibault, MP, Dubé, N, Faubert, D, Hipfner, DR, Gingras, AC, Cote, JF

Nat. Cell Biol. 2020
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GTPase activator activity of RHOJ GAPs [cytosol]

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