UTP + glutamine + ATP + H2O => CTP + glutamate + ADP + orthophosphate [CTPS]

Stable Identifier
R-HSA-73647
Type
Reaction [transition]
Species
Homo sapiens
Compartment
Synonyms
amination of uridine 5'-triphosphate (UTP) to form cytidine 5'-triphosphate (CTP)
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Cytosolic CTP synthase 1 (CTPS) catalyzes the reaction of UTP, glutamine, ATP and water to form CTP, glutamate, ADP, and orthophosphate (Han et al. 2005). The active form of the enzyme is a tetramer (Kursala et al. 2006). Both CTPS and a second human gene product, CPTS2, have CTP synthase activity in various test systems; their relative contributions to CTP metabolism in the body is not clear.

Literature References
PubMed ID Title Journal Year
16179339 Expression of Human CTP synthetase in Saccharomyces cerevisiae reveals phosphorylation by protein kinase A

Han, GS, Sreenivas, A, Choi, MG, Chang, YF, Martin, SS, Baldwin, EP, Carman, GM

J Biol Chem 2005
16820675 Structure of the synthetase domain of human CTP synthetase, a target for anticancer therapy

Kursula, P, Flodin, S, Ehn, M, Hammarström, M, Schüler, H, Nordlund, P, Stenmark, P

Acta Crystallogr Sect F Struct Biol Cryst Commun 2006
Participants
Participant Of
Catalyst Activity
Catalyst Activity
Title
CTP synthase activity of CTPS tetramer [cytosol]
Physical Entity
Activity
Orthologous Events
Cross References
Rhea
Created