Cytosolic CTP synthase 1 (CTPS) catalyzes the reaction of UTP, glutamine, ATP and water to form CTP, glutamate, ADP, and orthophosphate (Han et al. 2005). The active form of the enzyme is a tetramer (Kursala et al. 2006). Both CTPS and a second human gene product, CPTS2, have CTP synthase activity in various test systems; their relative contributions to CTP metabolism in the body is not clear.
Hammarström, M, Stenmark, P, Nordlund, P, Kursula, P, Schüler, H, Flodin, S, Ehn, M
Martin, SS, Baldwin, EP, Choi, MG, Carman, GM, Chang, YF, Sreenivas, A, Han, GS
CTP synthase activity of CTPS tetramer [cytosol]
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