Reactome | UTP + glutamine + ATP + H2O => CTP + glutamate + ADP + orthophosphate [CTPS]

UTP + glutamine + ATP + H2O => CTP + glutamate + ADP + orthophosphate [CTPS]

Stable Identifier

R-HSA-73647

Type

Reaction [transition]

Species

Homo sapiens

Compartment

cytosol

Synonyms

amination of uridine 5'-triphosphate (UTP) to form cytidine 5'-triphosphate (CTP)

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UTP + glutamine + ATP + H2O => CTP + glutamate + ADP + orthophosphate [CTPS]

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Cytosolic CTP synthase 1 (CTPS) catalyzes the reaction of UTP, glutamine, ATP and water to form CTP, glutamate, ADP, and orthophosphate (Han et al. 2005). The active form of the enzyme is a tetramer (Kursala et al. 2006). Both CTPS and a second human gene product, CPTS2, have CTP synthase activity in various test systems; their relative contributions to CTP metabolism in the body is not clear.

Literature References

PubMed ID	Title	Journal	Year
16179339	Expression of Human CTP synthetase in Saccharomyces cerevisiae reveals phosphorylation by protein kinase A Han, GS, Sreenivas, A, Choi, MG, Chang, YF, Martin, SS, Baldwin, EP, Carman, GM	J Biol Chem	2005
16820675	Structure of the synthetase domain of human CTP synthetase, a target for anticancer therapy Kursula, P, Flodin, S, Ehn, M, Hammarström, M, Schüler, H, Nordlund, P, Stenmark, P	Acta Crystallogr Sect F Struct Biol Cryst Commun	2006