Reactome | UTP + glutamine + ATP + H2O => CTP + glutamate + ADP + orthophosphate [CTPS]

UTP + glutamine + ATP + H2O => CTP + glutamate + ADP + orthophosphate [CTPS]

Stable Identifier

R-HSA-73647

Type

Reaction [transition]

Species

Homo sapiens

Compartment

cytosol

Synonyms

amination of uridine 5'-triphosphate (UTP) to form cytidine 5'-triphosphate (CTP)

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UTP + glutamine + ATP + H2O => CTP + glutamate + ADP + orthophosphate [CTPS]

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Cytosolic CTP synthase 1 (CTPS) catalyzes the reaction of UTP, glutamine, ATP and water to form CTP, glutamate, ADP, and orthophosphate (Han et al. 2005). The active form of the enzyme is a tetramer (Kursala et al. 2006). Both CTPS and a second human gene product, CPTS2, have CTP synthase activity in various test systems; their relative contributions to CTP metabolism in the body is not clear.

Literature References

PubMed ID	Title	Journal	Year
16820675	Structure of the synthetase domain of human CTP synthetase, a target for anticancer therapy Hammarström, M, Stenmark, P, Nordlund, P, Kursula, P, Schüler, H, Flodin, S, Ehn, M	Acta Crystallogr Sect F Struct Biol Cryst Commun	2006
16179339	Expression of Human CTP synthetase in Saccharomyces cerevisiae reveals phosphorylation by protein kinase A Martin, SS, Baldwin, EP, Choi, MG, Carman, GM, Chang, YF, Sreenivas, A, Han, GS	J Biol Chem	2005