Cytosolic CTP synthase 1 (CTPS) catalyzes the reaction of UTP, glutamine, ATP and water to form CTP, glutamate, ADP, and orthophosphate (Han et al. 2005). The active form of the enzyme is a tetramer (Kursala et al. 2006). Both CTPS and a second human gene product, CPTS2, have CTP synthase activity in various test systems; their relative contributions to CTP metabolism in the body is not clear.
Han, GS, Sreenivas, A, Choi, MG, Chang, YF, Martin, SS, Baldwin, EP, Carman, GM
Kursula, P, Flodin, S, Ehn, M, Hammarström, M, Schüler, H, Nordlund, P, Stenmark, P
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