UTP + glutamine + ATP + H2O => CTP + glutamate + ADP + orthophosphate [CTPS]

Stable Identifier
Reaction [transition]
Homo sapiens
amination of uridine 5'-triphosphate (UTP) to form cytidine 5'-triphosphate (CTP)
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Cytosolic CTP synthase 1 (CTPS) catalyzes the reaction of UTP, glutamine, ATP and water to form CTP, glutamate, ADP, and orthophosphate (Han et al. 2005). The active form of the enzyme is a tetramer (Kursala et al. 2006). Both CTPS and a second human gene product, CPTS2, have CTP synthase activity in various test systems; their relative contributions to CTP metabolism in the body is not clear.

Literature References
PubMed ID Title Journal Year
16820675 Structure of the synthetase domain of human CTP synthetase, a target for anticancer therapy

Hammarström, M, Stenmark, P, Nordlund, P, Kursula, P, Schüler, H, Flodin, S, Ehn, M

Acta Crystallogr Sect F Struct Biol Cryst Commun 2006
16179339 Expression of Human CTP synthetase in Saccharomyces cerevisiae reveals phosphorylation by protein kinase A

Martin, SS, Baldwin, EP, Choi, MG, Carman, GM, Chang, YF, Sreenivas, A, Han, GS

J Biol Chem 2005
Catalyst Activity

CTP synthase activity of CTPS tetramer [cytosol]

Orthologous Events
Cross References
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