abacavir [cytosol] + ATP + H2O => abacavir[extracellular] + ADP + phosphate

Stable Identifier
R-MMU-2161533
Type
Reaction [transition]
Species
Mus musculus
Compartment
cytosol, extracellular region, plasma membrane
Synonyms
Abcg2-mediated abacavir efflux
ReviewStatus
5/5
General
SVG | 
PNG
Low
Medium
High
 | PPTX  | SBGN
abacavir [cytosol] + ATP + H2O => abacavir[extracellular] + ADP + phosphate
ATP-binding cassette sub-family G member 2 (Abcg2), associated with the plasma membrane, mediates the ATP-dependent efflux of abacavir (Pan et al. 2007). The dimeric structure of the transporter is inferred from that of its human counterpart (Wakabayashi et al. 2007).
Literature References
PubMed ID Title Journal Year
17686774 Intramolecular disulfide bond is a critical check point determining degradative fates of ATP-binding cassette (ABC) transporter ABCG2 protein

Wakabayashi, K, Nakagawa, H, Tamura, A, Koshiba, S, Hoshijima, K, Komada, M, Ishikawa, T

J Biol Chem 2007
17437964 Abcg2/Bcrp1 mediates the polarized transport of antiretroviral nucleosides abacavir and zidovudine

Pan, G, Giri, N, Elmquist, WF

Drug Metab Dispos 2007
Participants
Input
Output
Catalyst Activity

ATPase-coupled transmembrane transporter activity of Abcg2 dimer [plasma membrane]

Physical Entity
Abcg2 dimer [plasma membrane] (Mus musculus)
Activity
ATPase-coupled transmembrane transporter activity (GO:0042626)
Orthologous Events
abacavir [cytosol] + ATP + H2O => abacavir[extracellular] + ADP + phosphate (Homo sapiens)
Authored
D'Eustachio, P  (2012-03-14)
Reviewed
Jassal, B  (2012-03-16)
Created
D'Eustachio, P  (2012-03-14)
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