Reactome | PtpA dephosphorylates GSK3A

PtpA dephosphorylates GSK3A

Stable Identifier

R-HSA-9635461

Type

Reaction [transition]

Species

Homo sapiens

Related Species

Mycobacterium tuberculosis

Compartment

cytosol

ReviewStatus

5/5

Locations in the PathwayBrowser

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Disease (Homo sapiens)

- Infectious disease (Homo sapiens)
  - Bacterial Infection Pathways (Homo sapiens)
    - Infection with Mycobacterium tuberculosis (Homo sapiens)
      - Response of Mtb to phagocytosis (Homo sapiens)
        
        Suppression of apoptosis (Homo sapiens)
        
        PtpA dephosphorylates GSK3A (Homo sapiens)

General

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Mtb infection inhibits the cleavage of inactive caspase-3 into its active forms by dephosphorylation of human glycogen synthase kinase-3 alpha (GSK3α). Tyr-279 is essential for the full activity of GSK3α. Mtb protein tyrosine phosphatase (PtpA) dephosphorylates Tyr-279 and thereby inactivates GSK3α (Poirier et al. 2014).

Literature References

PubMed ID	Title	Journal	Year
25187516	Mycobacterium tuberculosis promotes anti-apoptotic activity of the macrophage by PtpA protein-dependent dephosphorylation of host GSK3α Poirier, V, Av-Gay, Y, Bach, H	J. Biol. Chem.	2014

Participants

Input

Output

Participates

as an event of

Suppression of apoptosis (Homo sapiens)

Catalyst Activity

protein tyrosine phosphatase activity of PtpA [cytosol]

Physical Entity

PtpA [cytosol] (Mycobacterium tuberculosis)

Activity

protein tyrosine phosphatase activity (GO:0004725)

Disease

Name	Identifier	Synonyms
tuberculosis	DOID:399	tuberculous abscess, Tuberculoma (finding), tuberculoma

Authored

Stephan, R (2019-02-12)

Reviewed

Wilkinson, RJ (2019-10-23)

Deffur, A (2019-10-23)

Created

Pardo, AM (2019-02-05)

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