PtpA dephosphorylates GSK3A

Stable Identifier
R-HSA-9635461
Type
Reaction [transition]
Species
Homo sapiens
Related Species
Mycobacterium tuberculosis
Compartment
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Mtb infection inhibits the cleavage of inactive caspase-3 into its active forms by dephosphorylation of human glycogen synthase kinase-3 alpha (GSK3α). Tyr-279 is essential for the full activity of GSK3α. Mtb protein tyrosine phosphatase (PtpA) dephosphorylates Tyr-279 and thereby inactivates GSK3α (Poirier et al. 2014).

Literature References
Participants
Participant Of
Catalyst Activity
Catalyst Activity
Title
protein tyrosine phosphatase activity of PtpA [cytosol]
Physical Entity
Activity
Disease
Name Identifier Synonyms
tuberculosis 399 tuberculous abscess, Tuberculoma (finding), tuberculoma
Authored
Reviewed
Created
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