Reactome | ABCC3 transports bile salts from cytosol to extracellular region

ABCC3 transports bile salts from cytosol to extracellular region

Stable Identifier

R-HSA-194153

Type

Reaction [transition]

Species

Homo sapiens

Compartment

plasma membrane, cytosol, extracellular region

Synonyms

Efflux of bile salts from enterocytes to portal system by MRP3

ReviewStatus

5/5

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ABCC3 transports bile salts from cytosol to extracellular region

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A molecule of glycocholate, taurocholate, or taurochenodeoxycholate is transported from the cytosol to the extracellular space, coupled to the hydrolysis of a molecule of cytosolic ATP to ADP and orthophosphate. This reaction is mediated by ABCC3 (MRP3). In the body, this reaction mediates the release of bile salts from enterocytes into the blood (Kullak-Ublick et al. 2004; Trauner and Boyer 2002). In the cytosol, bile salts and acids are bound to a carrier protein, FABP6 (I-BABP) (Fujita et al. 1995), and in the blood these molecules are complexed with albumin. The mechanisms by which transport across the plasma membrane is coupled to release from FABP6 and binding to albumin are unknown, so the entire process is annotated as a single concerted event.

Literature References

PubMed ID	Title	Journal	Year
10987286	Transport of amphipathic anions by human multidrug resistance protein 3 Rea, PA, Zeng, H, Kruh, GD, Liu, G	Cancer Res	2000
12220224	Transport of bile acids in multidrug-resistance-protein 3-overexpressing cells co-transfected with the ileal Na+-dependent bile-acid transporter Borst, P, Kuil, A, Zelcer, N, Bot, I, Saeki, T	Biochem J	2003
12704183	Differential modulation of the human liver conjugate transporters MRP2 and MRP3 by bile acids and organic anions Sarkadi, B, Varadi, A, Szeri, F, Bodo, A, Bakos, E	J Biol Chem	2003