Transport (efflux) of bile salts by ABCC3 (MRP3)

Stable Identifier
R-HSA-194153
Type
Reaction [transition]
Species
Homo sapiens
Compartment
Locations in the PathwayBrowser
General
SVG |   | PPTX  | SBGN
Click the image above or here to open this reaction in the Pathway Browser
The layout of this reaction may differ from that in the pathway view due to the constraints in pathway layout

A molecule of glycocholate, taurocholate, or taurochenodeoxycholate is transported from the cytosol to the extracellular space, coupled to the hydrolysis of a molecule of cytosolic ATP to ADP and orthophosphate. This reaction is mediated by ABCB3 (MRP3). In the body, this reaction mediates the release of bile salts from enterocytes into the blood (Kullak-Ublick et al. 2004; Trauner and Boyer 2002). In the cytosol, bile salts and acids are bound to a carrier protein, FABP6 (I-BABP) (Fujita et al. 1995), and in the blood these molecules are complexed with albumin. The mechanisms by which transport across the plasma membrane is coupled to release FABP6 and binding to albumin are unknown, so the entire process is annotated as a single concerted event.

Literature References
PubMed ID Title Journal Year
12220224 Transport of bile acids in multidrug-resistance-protein 3-overexpressing cells co-transfected with the ileal Na+-dependent bile-acid transporter

Zelcer, N, Saeki, T, Bot, I, Kuil, A, Borst, P

Biochem J 2003
10987286 Transport of amphipathic anions by human multidrug resistance protein 3

Zeng, H, Liu, G, Rea, PA, Kruh, GD

Cancer Res 2000
12704183 Differential modulation of the human liver conjugate transporters MRP2 and MRP3 by bile acids and organic anions

Bodo, A, Bakos, E, Szeri, F, Varadi, A, Sarkadi, B

J Biol Chem 2003
Participants
Participant Of
Catalyst Activity
Catalyst Activity
Title
ATPase-coupled bile acid transmembrane transporter activity of ABCC3 [plasma membrane]
Physical Entity
Activity
Orthologous Events
Authored
Reviewed
Created
Cite Us!