I4P is dephosphorylated to Ins by IMPA1/2 in the cytosol

Stable Identifier
R-HSA-1855211
Type
Reaction [transition]
Species
Homo sapiens
Compartment
cytosol
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I4P is dephosphorylated to Ins by IMPA1/2 in the cytosol
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Inositol monophosphatase 1 (IMPA1) and 2 (IMPA2) homodimers dephosphorylate inositol 4-phosphate (I4P) to inositol (Ins). In vitro, IMPA1 and 2 differ in their pH optima and IMPA1 has a significantly greater activity on IP4 than does IMPA2 (Ohnishi et al. 2007).

Literature References
PubMed ID Title Journal Year
17068342 Spatial expression patterns and biochemical properties distinguish a second myo-inositol monophosphatase IMPA2 from IMPA1

Seo, KC, Sato, Y, Ohba, H, Ohnishi, T, Chung, SK, Furuichi, T, Im, J, Yoshikawa, T, Iwayama, Y

J Biol Chem 2007
Participants
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Output
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as an event of
Catalyst Activity

inositol monophosphate 4-phosphatase activity of IMPA1/2 [cytosol]

Physical Entity
IMPA1/2 [cytosol] (Homo sapiens)
Activity
inositol monophosphate 4-phosphatase activity (GO:0052833)
Orthologous Events
I4P is dephosphorylated to Ins by IMPA1/2 in the cytosol (Bos taurus)
I4P is dephosphorylated to Ins by IMPA1/2 in the cytosol (Caenorhabditis elegans)
I4P is dephosphorylated to Ins by IMPA1/2 in the cytosol (Canis familiaris)
I4P is dephosphorylated to Ins by IMPA1/2 in the cytosol (Danio rerio)
I4P is dephosphorylated to Ins by IMPA1/2 in the cytosol (Dictyostelium discoideum)
I4P is dephosphorylated to Ins by IMPA1/2 in the cytosol (Drosophila melanogaster)
I4P is dephosphorylated to Ins by IMPA1/2 in the cytosol (Gallus gallus)
I4P is dephosphorylated to Ins by IMPA1/2 in the cytosol (Mus musculus)
I4P is dephosphorylated to Ins by IMPA1/2 in the cytosol (Rattus norvegicus)
I4P is dephosphorylated to Ins by IMPA1/2 in the cytosol (Saccharomyces cerevisiae)
I4P is dephosphorylated to Ins by IMPA1/2 in the cytosol (Sus scrofa)
I4P is dephosphorylated to Ins by IMPA1/2 in the cytosol (Xenopus tropicalis)
Cross References
Rhea
Authored
Williams, MG  (2011-10-28)
Reviewed
Wundenberg, T  (2012-11-07)
Created
Williams, MG  (2011-10-28)
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