TBC1D25 accelerates GTP hydrolysis by RAB33B

Stable Identifier
R-HSA-8854612
Type
Reaction [transition]
Species
Homo sapiens
Compartment
Locations in the PathwayBrowser
General
SVG |   | PPTX  | SBGN
Click the image above or here to open this reaction in the Pathway Browser
The layout of this reaction may differ from that in the pathway view due to the constraints in pathway layout

RAB33B a medial Golgi-resident Rab involved in retrograde transport, is a target of TBC1D25 (OATL1). TBC1D25 significantly accelerates the GTP hydrolysis activity of RAB33B in a dose-dependent manner (Itoh et al. 2011).

Literature References
PubMed ID Title Journal Year
21383079 OATL1, a novel autophagosome-resident Rab33B-GAP, regulates autophagosomal maturation

Itoh, T, Kanno, E, Uemura, T, Waguri, S, Fukuda, M

J. Cell Biol. 2011
Participants
Participant Of
hasEvent
Catalyst Activity
Catalyst Activity
Title
GTPase activity of RAB33:GTP [Golgi membrane]
Physical Entity
Activity
This event is regulated
Positively by
Orthologous Events
Authored
Created