The ABCC family mediates organic anion transport

Stable Identifier
R-HSA-1454916
Type
Reaction [transition]
Species
Homo sapiens
Compartment
cytosol, extracellular region, plasma membrane
ReviewStatus
5/5
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The ABCC family mediates organic anion transport
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The multidrug resistance associated protein (MRPs) subfamily of the ABC transporter family can transport a wide and diverse range of organic anions that can be endogenous compounds and xenobiotics and their metabolites. All human MRPs (except MRP9) can mediate these transport reactions (Deeley et al. 2006). Separately, specific reactions have also been annotated to describe the roles of ABCC4 in platelet dense granule assembly, of ABCC1 in LTC4 export (an aspect of leukotriene synthesis), and of ABCC3 in bile salt efflux.
Literature References
PubMed ID Title Journal Year
16816140 Transmembrane transport of endo- and xenobiotics by mammalian ATP-binding cassette multidrug resistance proteins

Deeley, RG, Westlake, C, Cole, SP

Physiol Rev 2006
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Input
Output
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as an event of
Catalyst Activity

ATPase-coupled transmembrane transporter activity of ABCCs [plasma membrane]

Physical Entity
ABCCs [plasma membrane] (Homo sapiens)
Activity
ATPase-coupled transmembrane transporter activity (GO:0042626)
Orthologous Events
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The ABCC family mediates organic anion transport (Dictyostelium discoideum)
The ABCC family mediates organic anion transport (Drosophila melanogaster)
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The ABCC family mediates organic anion transport (Plasmodium falciparum)
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The ABCC family mediates organic anion transport (Saccharomyces cerevisiae)
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The ABCC family mediates organic anion transport (Sus scrofa)
The ABCC family mediates organic anion transport (Xenopus tropicalis)
Authored
Jassal, B  (2011-07-19)
Reviewed
D'Eustachio, P  (2011-08-23)
Created
Jassal, B  (2011-07-19)
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