abacavir [cytosol] + ATP + H2O => abacavir[extracellular] + ADP + phosphate

Stable Identifier
R-HSA-2161538
Type
Reaction [transition]
Species
Homo sapiens
Compartment
cytosol, extracellular region, plasma membrane
Synonyms
ABCB1-mediated abacavir efflux
ReviewStatus
5/5
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abacavir [cytosol] + ATP + H2O => abacavir[extracellular] + ADP + phosphate
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The ABCB1 transporter associated with the plasma membrane mediates the ATP-dependent efflux of a variety of xenobiotic molecules. Its ability to transport abacavir is inferred from studies of the corresponding mouse protein (Shaik et al. 2007).
Literature References
PubMed ID Title Journal Year
17709369 P-glycoprotein-mediated active efflux of the anti-HIV1 nucleoside abacavir limits cellular accumulation and brain distribution

Shaik, N, Giri, N, Pan, G, Elmquist, WF

Drug Metab Dispos 2007
Participants
Input
Output
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as an event of
Catalyst Activity

ATPase-coupled transmembrane transporter activity of ABCB1 [plasma membrane]

Physical Entity
ABCB1 [plasma membrane] (Homo sapiens)
Activity
ATPase-coupled transmembrane transporter activity (GO:0042626)
Inferred From
abacavir [cytosol] + ATP + H2O => abacavir[extracellular] + ADP + phosphate (Mus musculus)
Authored
D'Eustachio, P  (2012-03-14)
Reviewed
Jassal, B  (2012-03-16)
Created
D'Eustachio, P  (2012-03-14)
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