abacavir [cytosol] + ATP + H2O => abacavir[extracellular] + ADP + phosphate

Stable Identifier
R-HSA-2161538
Type
Reaction [transition]
Species
Homo sapiens
Compartment
Synonyms
ABCB1-mediated abacavir efflux
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The ABCB1 transporter associated with the plasma membrane mediates the ATP-dependent efflux of a variety of xenobiotic molecules. Its ability to transport abacavir is inferred from studies of the corresponding mouse protein (Shaik et al. 2007).

Literature References
PubMed ID Title Journal Year
17709369 P-glycoprotein-mediated active efflux of the anti-HIV1 nucleoside abacavir limits cellular accumulation and brain distribution

Shaik, N, Giri, N, Pan, G, Elmquist, WF

Drug Metab Dispos 2007
Participants
Participant Of
Catalyst Activity
Catalyst Activity
Title
ATPase-coupled xenobiotic transmembrane transporter activity of ABCB1 [plasma membrane]
Physical Entity
Activity
Inferred From
Authored
Reviewed
Created
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