Reactome | trans-Golgi Network Coat Assembly

trans-Golgi Network Coat Assembly

Stable Identifier

R-HSA-421831

Type

Reaction [dissociation]

Species

Homo sapiens

Compartment

Golgi membrane, cytosol

ReviewStatus

5/5

Locations in the PathwayBrowser

Expand all

General

SBML | | PDF

SVG | | PPTX | SBGN

Click the image above or here to open this reaction in the Pathway Browser
The layout of this reaction may differ from that in the pathway view due to the constraints in pathway layout

Once the basic components of the docking complex are assembled with one end of AP-1 bound to cargo molecules, the other end binds to clathrin. Clathrin triskelions polymerize into hexagons and pentagons, forming a cage, which leads to membrane deformation. This polymerization step drives the sculpting of the vesicle. The number of clathrin triskelions required to sculpt a vesicle appears to be variable, but has been estimated to require 36 - 60 triskelions assocaited with 30 - 66 AP-1 complexes. Here a ~380 angstroms vesicle is represented with 48 clathrin triskelions and 52 AP-1 complexes.

Literature References

PubMed ID	Title	Journal	Year
11994746	Regulated transport of the glucose transporter GLUT4. Bryant, NJ, Govers, R, James, DE	Nat Rev Mol Cell Biol	2002
10394364	Functional organization of clathrin in coats: combining electron cryomicroscopy and X-ray crystallography Musacchio, A, Smith, CJ, Roseman, AM, Harrison, SC, Kirchhausen, Tomas, Pearse, BM	Mol Cell	1999