trans-Golgi Network Coat Assembly

Stable Identifier
Reaction [dissociation]
Homo sapiens
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Once the basic components of the docking complex are assembled with one end of AP-1 bound to cargo molecules, the other end binds to clathrin. Clathrin triskelions polymerize into hexagons and pentagons, forming a cage, which leads to membrane deformation. This polymerization step drives the sculpting of the vesicle. The number of clathrin triskelions required to sculpt a vesicle appears to be variable, but has been estimated to require 36 - 60 triskelions assocaited with 30 - 66 AP-1 complexes. Here a ~380 angstroms vesicle is represented with 48 clathrin triskelions and 52 AP-1 complexes.

Literature References
PubMed ID Title Journal Year
11994746 Regulated transport of the glucose transporter GLUT4.

James, DE, Bryant, NJ, Govers, R

Nat Rev Mol Cell Biol 2002
10394364 Functional organization of clathrin in coats: combining electron cryomicroscopy and X-ray crystallography

Roseman, AM, Pearse, BM, Smith, CJ, Musacchio, A, Kirchhausen, Tomas, Harrison, SC

Mol Cell 1999
Orthologous Events
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