trans-Golgi Network Coat Assembly

Stable Identifier
R-HSA-421831
Type
Reaction [dissociation]
Species
Homo sapiens
Compartment
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Once the basic components of the docking complex are assembled with one end of AP-1 bound to cargo molecules, the other end binds to clathrin. Clathrin triskelions polymerize into hexagons and pentagons, forming a cage, which leads to membrane deformation. This polymerization step drives the sculpting of the vesicle. The number of clathrin triskelions required to sculpt a vesicle appears to be variable, but has been estimated to require 36 - 60 triskelions assocaited with 30 - 66 AP-1 complexes. Here a ~380 angstroms vesicle is represented with 48 clathrin triskelions and 52 AP-1 complexes.

Literature References
PubMed ID Title Journal Year
10394364 Functional organization of clathrin in coats: combining electron cryomicroscopy and X-ray crystallography

Musacchio, A, Smith, CJ, Roseman, AM, Harrison, SC, Kirchhausen, Tomas, Pearse, BM

Mol Cell 1999
11994746 Regulated transport of the glucose transporter GLUT4.

Bryant, NJ, Govers, R, James, DE

Nat Rev Mol Cell Biol 2002
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