RAN stimulates fusion of nuclear envelope (NE) membranes

Stable Identifier
R-HSA-9624893
Type
Reaction [transition]
Species
Homo sapiens
Compartment
cytosol, nuclear envelope
ReviewStatus
5/5
Locations in the PathwayBrowser
Expand all
General
SVG | 
PNG
Low
Medium
High
 | PPTX  | SBGN
RAN stimulates fusion of nuclear envelope (NE) membranes
Click the image above or here to open this reaction in the Pathway Browser
The layout of this reaction may differ from that in the pathway view due to the constraints in pathway layout

RAN GTPase, stimulated by SUMO-coupled RANGAP1 promotes fusion of NE vesicles in an in vitro reassembly assay (Zhang and Clarke 2001).

Literature References
Participants
Input
Output
Participates
as an event of
Catalyst Activity

GTPase activator activity of SUMO1:RANGAP1 homodimer [nuclear envelope]

Physical Entity
SUMO1:RANGAP1 homodimer [nuclear envelope] (Homo sapiens)
Activity
GTPase activator activity (GO:0005096)
Orthologous Events
RAN stimulates fusion of nuclear envelope (NE) membranes (Bos taurus)
RAN stimulates fusion of nuclear envelope (NE) membranes (Caenorhabditis elegans)
RAN stimulates fusion of nuclear envelope (NE) membranes (Danio rerio)
RAN stimulates fusion of nuclear envelope (NE) membranes (Dictyostelium discoideum)
RAN stimulates fusion of nuclear envelope (NE) membranes (Drosophila melanogaster)
RAN stimulates fusion of nuclear envelope (NE) membranes (Gallus gallus)
RAN stimulates fusion of nuclear envelope (NE) membranes (Mus musculus)
RAN stimulates fusion of nuclear envelope (NE) membranes (Rattus norvegicus)
RAN stimulates fusion of nuclear envelope (NE) membranes (Saccharomyces cerevisiae)
RAN stimulates fusion of nuclear envelope (NE) membranes (Schizosaccharomyces pombe)
RAN stimulates fusion of nuclear envelope (NE) membranes (Sus scrofa)
Authored
Gerace, L  (2019-11-07)
Created
Orlic-Milacic, M  (2018-10-16)
Cite Us!