Atp7a transfers Cu from Atox1 to Sod3

Stable Identifier
R-MMU-3697899
Type
Reaction [omitted]
Species
Mus musculus
Compartment
Golgi lumen, cytosol, trans-Golgi network membrane
ReviewStatus
5/5
General
SVG | 
PNG
Low
Medium
High
 | PPTX  | SBGN
Atp7a transfers Cu from Atox1 to Sod3
Atp7a (Menke's ATPase, Mnk) transports copper from Atox in the cytosol to Sod3 in the lumen of the trans golgi network (Jeney et al. 2005, Qin et al. 2006, Qin et al. 2008, Itoh et al. 2009). Atp7a and Sod3 directly interact.
Literature References
PubMed ID Title Journal Year
18977292 Novel mechanism for regulation of extracellular SOD transcription and activity by copper: role of antioxidant-1

Itoh, S, Ozumi, K, Kim, HW, Nakagawa, O, McKinney, RD, Folz, RJ, Zelko, IN, Ushio-Fukai, M, Fukai, T

Free Radic. Biol. Med. 2009
15761197 Role of antioxidant-1 in extracellular superoxide dismutase function and expression

Jeney, V, Itoh, S, Wendt, M, Gradek, Q, Ushio-Fukai, M, Harrison, DG, Fukai, T

Circ. Res. 2005
16371425 Essential role for the Menkes ATPase in activation of extracellular superoxide dismutase: implication for vascular oxidative stress

Qin, Z, Itoh, S, Jeney, V, Ushio-Fukai, M, Fukai, T

FASEB J. 2006
18768397 Role of Menkes ATPase in angiotensin II-induced hypertension: a key modulator for extracellular superoxide dismutase function

Qin, Z, Gongora, MC, Ozumi, K, Itoh, S, Akram, K, Ushio-Fukai, M, Harrison, DG, Fukai, T

Hypertension 2008
Participants
Input
Output
Orthologous Events
ATP7A transfers Cu from ATOX1 to SOD3 (Homo sapiens)
Authored
May, B  (2013-06-09)
Reviewed
Kavdia, M  (2013-11-01)
Created
May, B  (2013-06-09)
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